Fabrication of magnetic drug-loaded polymeric composite nanofibres and their drug release characteristics

Linge Wang, Meng Wang, Paul D. Topham, Yong Huang

Research output: Contribution to journalArticle

Abstract

Magnetic polymer nanofibres intended for drug delivery have been designed and fabricated by electrospinning. Magnetite (Fe3O4) nanoparticles were successfully incorporated into electrospun nanofibre composites of two cellulose derivatives, dehydroxypropyl methyl cellulose phthalate (HPMCP) and cellulose acetate (CA), while indomethacin (IDN) and aspirin have been used as model drugs. The morphology of the neat and magnetic drug-loaded electrospun fibres and the release characteristics of the drugs in artificial intestinal juice were investigated. It was found that both types of electrospun composite nanofibres containing magnetite nanoparticles showed superparamagnetism at room temperature, and their saturation magnetisation and morphology depend on the Fe3O4 nanoparticle content. Furthermore, the presence of the magnetite nanoparticles did not affect the drug release profiles of the nanofibrous devices. The feasibility of controlled drug release to a target area of treatment under the guidance of an external magnetic field has also been demonstrated, showing the viability of the concept of magnetic drug-loaded polymeric composite nanofibres for magneto-chemotherapy.

LanguageEnglish
Pages2433-2438
Number of pages6
JournalRSC advances
Volume2
Issue number6
Early online date2 Feb 2012
DOIs
Publication statusPublished - 14 Mar 2012

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Nanofibers
Magnetite nanoparticles
Fabrication
Composite materials
Magnetite Nanoparticles
Pharmaceutical Preparations
Cellulose
Superparamagnetism
Cellulose derivatives
Chemotherapy
Electrospinning
Saturation magnetization
Drug delivery
Methylcellulose
Magnetic fields
Nanoparticles
Indomethacin
Aspirin
Fibers
Polymers

Cite this

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title = "Fabrication of magnetic drug-loaded polymeric composite nanofibres and their drug release characteristics",
abstract = "Magnetic polymer nanofibres intended for drug delivery have been designed and fabricated by electrospinning. Magnetite (Fe3O4) nanoparticles were successfully incorporated into electrospun nanofibre composites of two cellulose derivatives, dehydroxypropyl methyl cellulose phthalate (HPMCP) and cellulose acetate (CA), while indomethacin (IDN) and aspirin have been used as model drugs. The morphology of the neat and magnetic drug-loaded electrospun fibres and the release characteristics of the drugs in artificial intestinal juice were investigated. It was found that both types of electrospun composite nanofibres containing magnetite nanoparticles showed superparamagnetism at room temperature, and their saturation magnetisation and morphology depend on the Fe3O4 nanoparticle content. Furthermore, the presence of the magnetite nanoparticles did not affect the drug release profiles of the nanofibrous devices. The feasibility of controlled drug release to a target area of treatment under the guidance of an external magnetic field has also been demonstrated, showing the viability of the concept of magnetic drug-loaded polymeric composite nanofibres for magneto-chemotherapy.",
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Fabrication of magnetic drug-loaded polymeric composite nanofibres and their drug release characteristics. / Wang, Linge; Wang, Meng; Topham, Paul D.; Huang, Yong.

In: RSC advances, Vol. 2, No. 6, 14.03.2012, p. 2433-2438.

Research output: Contribution to journalArticle

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AU - Wang, Meng

AU - Topham, Paul D.

AU - Huang, Yong

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