Factors associated with chronic depressive symptoms across adolescence and young adulthood: a UK birth cohort study

B. B. Durdurak; B. Williams; A. Zhigalov; A. Moore; P. Mallikarjun; D. Wong; S. Marwaha; I. Morales-Muñoz

doi:10.1017/S2045796024000350

Factors associated with chronic depressive symptoms across adolescence and young adulthood: a UK birth cohort study

B. B. Durdurak, B. Williams, A. Zhigalov, A. Moore, P. Mallikarjun, D. Wong, S. Marwaha, I. Morales-Muñoz

Institute for Mental Health, School of Psychology, University of Birmingham, Edgbaston, Birmingham, United Kingdom; Orygen, Melbourne, Australia; Centre for Youth Mental Health, University of Melbourne, Australia
Department of Psychiatry, University of Cambridge Herchel Smith Building for Brain & Mind Sciences, Cambridge, UK.
Institute for Mental Health, University of Birmingham, UK; and Early Intervention Service, Birmingham Women's and Children's NHS Foundation Trust, UK.
Leeds Institute of Health Sciences, School of Medicine, University of Leeds, Leeds, UK.
Specialist Mood Disorders Clinic, The Barberry Centre for Mental Health, Birmingham and Solihull NHS Trust, Birmingham, UK.

Research output: Contribution to journal › Article › peer-review

2 Citations (SciVal)

10 Downloads (Pure)

Abstract

AIMS: Identifying children and/or adolescents who are at highest risk for developing chronic depression is of utmost importance, so that we can develop more effective and targeted interventions to attenuate the risk trajectory of depression. To address this, the objective of this study was to identify young people with persistent depressive symptoms across adolescence and young adulthood and examine the prospective associations between factors and persistent depressive symptoms in young people. METHODS: We used data from 6711 participants in the Avon Longitudinal Study of Parents and Children. Depressive symptoms were assessed at 12.5, 13.5, 16, 17.5, 21 and 22 years with the Short Mood and Feelings Questionnaire, and we further examined the influence of multiple biological, psychological and social factors in explaining chronic depressive symptoms. RESULTS: Using latent class growth analysis, we identified four trajectories of depressive symptoms: persistent high, persistent low, persistent moderate and increasing high. After applying several logistic regression models, we found that loneliness and feeling less connected at school were the most relevant factors for chronic course of depressive symptoms. CONCLUSIONS: Our findings contribute with the identification of those children who are at highest risk for developing chronic depressive symptoms.

Original language	English
Article number	e32
Number of pages	11
Journal	Epidemiology and psychiatric sciences
Volume	33
Early online date	26 Jun 2024
DOIs	https://doi.org/10.1017/S2045796024000350
Publication status	Published - 26 Jun 2024

Bibliographical note

Copyright © The Author(s), 2024. Published by Cambridge University Press. This is an Open
Access article, distributed under the terms of the Creative Commons Attribution licence
(https://creativecommons.org/licenses/by/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.

Data Access Statement

Access to ALSPAC data is through a system of managed open access (http://www.bristol.ac.uk/alspac/researchers/access/).

Funding

This study was funded by the Wellcome Trust (Grant ref.: 226698/Z/22/Z) and supported by the NIHR Mental Health Translational Research Collaboration. The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care. The ALSPAC was supported by the UK Medical Research Council and Wellcome (Grant ref.: 217065/Z/19/Z), and the University of Bristol provided core support for ALSPAC. SM is supported by the NIHR Oxford Biomedical Research Centre. The funders of the study had no role in the study design, data collection, data analysis, data interpretation or writing of the report. A comprehensive list of grants funding is available on the ALSPAC website (http://www.bristol.ac.uk/alspac/external/documents/grant-acknowledgements.pdf).

Keywords

ALSPAC
depressive symptoms
factors
trajectories
young people

Access to Document

10.1017/S2045796024000350

BB Durdurak et al_factors-associated-with-chronic-depressive-symptoms-across-adolescence-and-young-adulthood-a-uk-birth-cohort-study
Copyright © The Author(s), 2024. Published by Cambridge University Press. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.
Final published version, 510 KBLicence: CC BY 4.0

Cite this

@article{dfd977b12bcb4dee810eff46825cbc8b,

title = "Factors associated with chronic depressive symptoms across adolescence and young adulthood: a UK birth cohort study",

abstract = "AIMS: Identifying children and/or adolescents who are at highest risk for developing chronic depression is of utmost importance, so that we can develop more effective and targeted interventions to attenuate the risk trajectory of depression. To address this, the objective of this study was to identify young people with persistent depressive symptoms across adolescence and young adulthood and examine the prospective associations between factors and persistent depressive symptoms in young people. METHODS: We used data from 6711 participants in the Avon Longitudinal Study of Parents and Children. Depressive symptoms were assessed at 12.5, 13.5, 16, 17.5, 21 and 22 years with the Short Mood and Feelings Questionnaire, and we further examined the influence of multiple biological, psychological and social factors in explaining chronic depressive symptoms. RESULTS: Using latent class growth analysis, we identified four trajectories of depressive symptoms: persistent high, persistent low, persistent moderate and increasing high. After applying several logistic regression models, we found that loneliness and feeling less connected at school were the most relevant factors for chronic course of depressive symptoms. CONCLUSIONS: Our findings contribute with the identification of those children who are at highest risk for developing chronic depressive symptoms.",

keywords = "ALSPAC, depressive symptoms, factors, trajectories, young people",

author = "Durdurak, {B. B.} and B. Williams and A. Zhigalov and A. Moore and P. Mallikarjun and D. Wong and S. Marwaha and I. Morales-Mu{\~n}oz",

note = "Copyright {\textcopyright} The Author(s), 2024. Published by Cambridge University Press. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.",

year = "2024",

month = jun,

day = "26",

doi = "10.1017/S2045796024000350",

language = "English",

volume = "33",

journal = "Epidemiology and psychiatric sciences",

issn = "2045-7979",

publisher = "Cambridge University Press",

}

TY - JOUR

T1 - Factors associated with chronic depressive symptoms across adolescence and young adulthood: a UK birth cohort study

AU - Durdurak, B. B.

AU - Williams, B.

AU - Zhigalov, A.

AU - Moore, A.

AU - Mallikarjun, P.

AU - Wong, D.

AU - Marwaha, S.

AU - Morales-Muñoz, I.

N1 - Copyright © The Author(s), 2024. Published by Cambridge University Press. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.

PY - 2024/6/26

Y1 - 2024/6/26

N2 - AIMS: Identifying children and/or adolescents who are at highest risk for developing chronic depression is of utmost importance, so that we can develop more effective and targeted interventions to attenuate the risk trajectory of depression. To address this, the objective of this study was to identify young people with persistent depressive symptoms across adolescence and young adulthood and examine the prospective associations between factors and persistent depressive symptoms in young people. METHODS: We used data from 6711 participants in the Avon Longitudinal Study of Parents and Children. Depressive symptoms were assessed at 12.5, 13.5, 16, 17.5, 21 and 22 years with the Short Mood and Feelings Questionnaire, and we further examined the influence of multiple biological, psychological and social factors in explaining chronic depressive symptoms. RESULTS: Using latent class growth analysis, we identified four trajectories of depressive symptoms: persistent high, persistent low, persistent moderate and increasing high. After applying several logistic regression models, we found that loneliness and feeling less connected at school were the most relevant factors for chronic course of depressive symptoms. CONCLUSIONS: Our findings contribute with the identification of those children who are at highest risk for developing chronic depressive symptoms.

AB - AIMS: Identifying children and/or adolescents who are at highest risk for developing chronic depression is of utmost importance, so that we can develop more effective and targeted interventions to attenuate the risk trajectory of depression. To address this, the objective of this study was to identify young people with persistent depressive symptoms across adolescence and young adulthood and examine the prospective associations between factors and persistent depressive symptoms in young people. METHODS: We used data from 6711 participants in the Avon Longitudinal Study of Parents and Children. Depressive symptoms were assessed at 12.5, 13.5, 16, 17.5, 21 and 22 years with the Short Mood and Feelings Questionnaire, and we further examined the influence of multiple biological, psychological and social factors in explaining chronic depressive symptoms. RESULTS: Using latent class growth analysis, we identified four trajectories of depressive symptoms: persistent high, persistent low, persistent moderate and increasing high. After applying several logistic regression models, we found that loneliness and feeling less connected at school were the most relevant factors for chronic course of depressive symptoms. CONCLUSIONS: Our findings contribute with the identification of those children who are at highest risk for developing chronic depressive symptoms.

KW - ALSPAC

KW - depressive symptoms

KW - factors

KW - trajectories

KW - young people

UR - https://www.cambridge.org/core/journals/epidemiology-and-psychiatric-sciences/article/factors-associated-with-chronic-depressive-symptoms-across-adolescence-and-young-adulthood-a-uk-birth-cohort-study/D7F2FAD9139470B8055184C1E9AF7451

UR - http://www.scopus.com/inward/record.url?scp=85197094745&partnerID=8YFLogxK

U2 - 10.1017/S2045796024000350

DO - 10.1017/S2045796024000350

M3 - Article

C2 - 38920396

SN - 2045-7979

VL - 33

JO - Epidemiology and psychiatric sciences

JF - Epidemiology and psychiatric sciences

M1 - e32

ER -

Factors associated with chronic depressive symptoms across adolescence and young adulthood: a UK birth cohort study

Abstract

Bibliographical note

Data Access Statement

Funding

Keywords

Access to Document

Other files and links

Fingerprint

Cite this