Factors determining the morphology of β-amyloid (Aβ) deposits in Down's syndrome

Richard A. Armstrong*

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Immunostained preparations of the medial temporal lobe from patients with Down's syndrome (DS) were counterstained with cresyl violet to reveal the β-amyloid (Aβ) deposits and their associated cell populations. Aβ deposits in the cornu Ammonis (CA) of the hippocampus were, on average, more strongly stained, less often directly associated with neurons and more often associated with glial cells than the adjacent areas of cortex. Cored deposits were more frequently recorded in sulci rather than gyri and were associated with more glial cells than the uncored deposits. Multiple regression analyses suggested there was a positive correlation in the cortex between Aβ deposit size and the frequency of closely associated neurons, the correlation being most significant with larger (>25 μm) neurons. The morphology of Aβ deposit was also correlated with the location of deposits in the cortex, CA and dentate gyrus but this factor was of lesser importance. No significant variation in the morphology of the Aβ deposits was associated with the presence of blood vessels within or adjacent to the deposit. The data suggest that neuronal cell bodies are important in the initial formation of Aβ deposits and glial cells with the development of more mature amyloid deposits.

Original languageEnglish
Pages (from-to)179-186
Number of pages8
JournalExperimental Neurology
Volume4
Issue number2
DOIs
Publication statusPublished - Jun 1995

Keywords

  • Aβ deposit morphology
  • cell bodies
  • Down's syndrome
  • glial cells
  • multiple regression
  • neurons

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