Fat Hormones, Adipokines

I. Kyrou*, H. S. Mattu, K. Chatha, H. S. Randeva

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Adipose tissue functions as a dynamic endocrine organ secreting multiple proteins, factors, and hormones into the systemic circulation that are collectively described as adipokines. Adipokines exert pleiotropic effects on target tissues/organs thereby regulating energy homeostasis, metabolism, and insulin sensitivity, as well as immune and cardiovascular functions. Expanding adipose tissue in obesity undergoes a change in the adipokine secretion profile characterized by an increase of proinflammatory adipokines and suppression of anti-inflammatory adipokines increasing proinflammatory pathways within adipose tissue depots and creating an adverse circulating adipokine profile, resulting in a chronic, low-grade, systemic inflammatory state. Compelling evidence directly links the adverse proinflammatory adipokine profile in obesity with a spectrum of detrimental cardio-metabolic effects including hepatic, skeletal muscle, and myocardial insulin resistance, hypertension, atherosclerosis, hypercoagulability, thrombosis, and endothelial and cardiac dysfunction. This chapter presents a brief overview of the nature of adipose tissue in obesity and focuses on selected adipokines that have direct and indirect effects on the heart and cardiovascular system.

Original languageEnglish
Title of host publicationEndocrinology of the Heart in Health and Disease: Integrated, Cellular, and Molecular Endocrinology of the Heart
EditorsJonathan Schisler, Charles Lang, Monte Willis
PublisherElsevier
Pages167-205
Number of pages39
ISBN (Electronic)9780128031124
ISBN (Print)9780128031117
DOIs
Publication statusPublished - 4 Nov 2016

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Keywords

  • A-FABP
  • Adipokines
  • Adiponectin
  • Chemerin
  • Heart
  • Leptin
  • Obesity
  • Omentin
  • Resistin
  • Vaspin
  • Visfatin

Cite this

Kyrou, I., Mattu, H. S., Chatha, K., & Randeva, H. S. (2016). Fat Hormones, Adipokines. In J. Schisler, C. Lang, & M. Willis (Eds.), Endocrinology of the Heart in Health and Disease: Integrated, Cellular, and Molecular Endocrinology of the Heart (pp. 167-205). Elsevier. https://doi.org/10.1016/B978-0-12-803111-7.00007-5