Firewater, fructose and appetite

Emma L. Shepherd; Patricia F. Lalor

doi:10.1038/s42255-025-01369-9

Firewater, fructose and appetite

Research output: Contribution to journal › Article › peer-review

Abstract

A new study in mice links ethanol consumption to endogenous fructose generation via hepatic aldose reductase, which enhances alcohol-seeking behaviour and liver damage. Inhibition of ketohexokinase reduced these effects, highlighting potential targets for managing alcohol use disorders.

Original language	English
Pages (from-to)	2187-2188
Number of pages	2
Journal	Nature Metabolism
Volume	7
Issue number	11
Early online date	10 Nov 2025
DOIs	https://doi.org/10.1038/s42255-025-01369-9
Publication status	Published - 10 Nov 2025

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Firewater, fructose and appetite

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