Abstract
Type 2 diabetes is typically associated with insulin resistance and dysfunction of insulin-secreting pancreatic beta-cells. Addressing these defects often requires therapy with a combination of differently acting antidiabetic agents. A potential novel combination in development brings together the dipeptidyl peptidase-4 (DPP-4) inhibitor sitagliptin with the thiazolidinedione pioglitazone into a fixed-dose single-tablet combination. The former component acts mainly to increase prandial insulin secretion; the latter improves insulin sensitivity.
| Original language | English |
|---|---|
| Pages (from-to) | 1017-1025 |
| Number of pages | 9 |
| Journal | Expert Opinion on Investigational Drugs: authoritative analysis of r and d trends |
| Volume | 19 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Aug 2010 |
Keywords
- Animals
- Clinical Trials as Topic
- Diabetes Mellitus, Type 2
- Dipeptidyl-Peptidase IV Inhibitors
- Drug Therapy, Combination
- Female
- Humans
- Hypoglycemia
- Hypoglycemic Agents
- Insulin Resistance
- Male
- Pyrazines
- Thiazolidinediones
- Triazoles
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Cite this
Bailey, C. J., Green, B. D., & Flatt, P. R. (2010). Fixed-dose combination therapy for type 2 diabetes: sitagliptin plus pioglitazone. Expert Opinion on Investigational Drugs: authoritative analysis of r and d trends , 19(8), 1017-1025. https://doi.org/10.1517/13543784.2010.505235