Free radical reaction products and antioxidant capacity in beating heart coronary artery surgery compared to conventional bypass

A. Gonenc, A. HacIşevki, H.R. Griffiths, M. Torun, B. Bakkaloglu, B. Simsek

Research output: Contribution to journalArticle

Abstract

Oxygen-derived free radicals are important agents of tissue injury during ischemia and reperfusion. The aim of this study was to investigate changes in protein and lipid oxidation and antioxidant status in beating heart coronary artery surgery and conventional bypass and to compare oxidative stress parameters between the two bypass methods. Serum lipid hydroperoxide, nitric oxide, protein carbonyl, nitrotyrosine, vitamin E, and β-carotene levels and total antioxidant capacity were measured in blood of 30 patients undergoing beating heart coronary artery surgery (OPCAB, off-pump coronary artery bypass grafting) and 12 patients undergoing conventional bypass (CABG, on-pump coronary artery bypass grafting). In the OPCAB group, nitric oxide and nitrotyrosine levels decreased after reperfusion. Similarly, β-carotene level and total antioxidant capacity also decreased after anesthesia and reperfusion. In the CABG group, nitric oxide and nitrotyrosine levels decreased after ischemia and reperfusion. However, protein carbonyl levels elevated after ischemia and reperfusion. Vitamin E, β-carotene, and total antioxidant capacity decreased after ischemia and reperfusion. Significantly decreased nitration and impaired antioxidant status were seen after reperfusion in both groups. Moreover, elevated protein carbonyls were found in the CABG group. The off-pump procedure is associated with lower degree of oxidative stress than on-pump coronary surgery.

LanguageEnglish
Pages677-685
Number of pages9
JournalБиохимия/Biochemistry
Volume76
Issue number6
DOIs
Publication statusPublished - 17 Jun 2011

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Free radical reactions
Reaction products
Coronary Artery Bypass
Surgery
Reperfusion
Free Radicals
Coronary Vessels
Antioxidants
Pumps
beta Carotene
Off-Pump Coronary Artery Bypass
Nitric Oxide
Ischemia
Oxidative stress
Vitamin E
Proteins
Oxidative Stress
Nitration
Lipid Peroxides
Reperfusion Injury

Keywords

  • antioxidant
  • coronary artery bypass
  • nitrotyrosine
  • oxidative stress
  • protein carbonyls

Cite this

Gonenc, A. ; HacIşevki, A. ; Griffiths, H.R. ; Torun, M. ; Bakkaloglu, B. ; Simsek, B. / Free radical reaction products and antioxidant capacity in beating heart coronary artery surgery compared to conventional bypass. In: Биохимия/Biochemistry. 2011 ; Vol. 76, No. 6. pp. 677-685.
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Free radical reaction products and antioxidant capacity in beating heart coronary artery surgery compared to conventional bypass. / Gonenc, A.; HacIşevki, A.; Griffiths, H.R.; Torun, M.; Bakkaloglu, B.; Simsek, B.

In: Биохимия/Biochemistry, Vol. 76, No. 6, 17.06.2011, p. 677-685.

Research output: Contribution to journalArticle

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