Free radicals and redox signalling in T-cells during chronic inflammation and ageing

Helen R Griffiths, Christopher R Dunston, Stuart J Bennett, Melissa M. Grant, Darren C. Phillips, George D. Kitas

Research output: Contribution to journalArticlepeer-review

Abstract

During chronic inflammation and ageing, the increase in oxidative stress in both intracellular and extracellular compartments is likely to influence local cell functions. Redox changes alter the T-cell proteome in a quantitative and qualitative manner, and post-translational modifications to surface and cytoplasmic proteins by increased reactive species can influence T-cell function. Previously, we have shown that RA (rheumatoid arthritis) T-cells exhibit reduced ROS (reactive oxygen species) production in response to extracellular stimulation compared with age-matched controls, and basal ROS levels [measured as DCF (2',7'-dichlorofluorescein) fluorescence] are lower in RA T-cells. In contrast, exposing T-cells in vitro to different extracellular redox environments modulates intracellular signalling and enhances cytokine secretion. Together, these data suggest that a complex relationship exists between intra- and extra-cellular redox compartments which contribute to the T-cell phenotype.
Original languageEnglish
Pages (from-to)1273-1278
Number of pages6
JournalBiochemical Society Transactions
Volume39
Issue number5
DOIs
Publication statusPublished - Oct 2011

Keywords

  • aging
  • free radicals
  • humans
  • inflammation
  • oxidation-reduction
  • oxidative stress
  • reactive oxygen species
  • signal transduction
  • T-lymphocytes

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