Abstract
Small-molecule crystallography plays a significant part in the design of drugs, especially those which bind tightly to receptors. In some cases, the macromolecular target structure is unknown. In others, structural properties of the drug are required to regulate solubility or polymorphism. Several examples are given.
| Original language | English |
|---|---|
| Pages (from-to) | 49-60 |
| Number of pages | 12 |
| Journal | Crystallography Reviews |
| Volume | 11 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1 Jan 2005 |
Keywords
- Drug design
- Hydrogen bonding
- Polymorphism
- Small-molecule crystallography