From small molecule structures to medicines

Carl H. Schwalbe*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Small-molecule crystallography plays a significant part in the design of drugs, especially those which bind tightly to receptors. In some cases, the macromolecular target structure is unknown. In others, structural properties of the drug are required to regulate solubility or polymorphism. Several examples are given.

Original languageEnglish
Pages (from-to)49-60
Number of pages12
JournalCrystallography Reviews
Issue number1
Publication statusPublished - 1 Jan 2005


  • Drug design
  • Hydrogen bonding
  • Polymorphism
  • Small-molecule crystallography


Dive into the research topics of 'From small molecule structures to medicines'. Together they form a unique fingerprint.

Cite this