From small molecule structures to medicines

Carl H. Schwalbe

doi:10.1080/08893110500078456

From small molecule structures to medicines

Carl H. Schwalbe^*

^*Corresponding author for this work

Aston Pharmacy School

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Small-molecule crystallography plays a significant part in the design of drugs, especially those which bind tightly to receptors. In some cases, the macromolecular target structure is unknown. In others, structural properties of the drug are required to regulate solubility or polymorphism. Several examples are given.

Original language	English
Pages (from-to)	49-60
Number of pages	12
Journal	Crystallography Reviews
Volume	11
Issue number	1
DOIs	https://doi.org/10.1080/08893110500078456
Publication status	Published - 1 Jan 2005

Keywords

Drug design
Hydrogen bonding
Polymorphism
Small-molecule crystallography

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10.1080/08893110500078456

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KW - Hydrogen bonding

KW - Polymorphism

KW - Small-molecule crystallography

UR - https://www.scopus.com/pages/publications/17144372601

UR - https://www.tandfonline.com/doi/full/10.1080/08893110500078456

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From small molecule structures to medicines

Abstract

Keywords

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