Function of lipids - their fate in contact lens wear: an interpretive review

Amandeep Panaser*, Brian J. Tighe

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Lipids play a vital role in the body at many interfaces. Examples include the lubrication of articulating joints by synovial fluid, the coating of the lung by pulmonary surfactant and the functions of the tear film in the protection of the anterior eye. The role of the lipids is similar at each site - acting as boundary lubricants and reducing surface and interfacial tension. This review focuses on how and why contact lens wear can disrupt the normal function of lipids within the tear film and explains how the otherwise advantageous presence and function of tear lipids can become disadvantageous, causing problems for the wearer. Because the contact lens is some ten times thicker than the tear film, lipids deposited on the anterior surface become immobilised, reducing lipid turnover and thus leading to prolonged exposure to oxygen and light with consequent generation of degradation products. These degraded lipids reduce lens wettability and have additionally been linked to problems of contact lens discomfort and intolerance. Lipid problems are influenced by the thickness of the lens, the material, surface modification, mode of wear and ultimately the subject. The most influential of these variables is frequently the subject.

Original languageEnglish
Pages (from-to)100-111
Number of pages12
JournalContact Lens and Anterior Eye
Volume35
Issue number3
Early online date10 Feb 2012
DOIs
Publication statusPublished - Jun 2012

Fingerprint

Contact Lenses
Lipids
Tears
Surface Tension
Lenses
Wettability
Lubrication
Pulmonary Surfactants
Lubricants
Synovial Fluid
Joints
Oxygen
Light
Lung

Keywords

  • contact lens intolerance
  • lipid oxidation
  • meibomian gland
  • tear lipids

Cite this

@article{55c99a40e4b144b4b1aca1fbdbf56872,
title = "Function of lipids - their fate in contact lens wear: an interpretive review",
abstract = "Lipids play a vital role in the body at many interfaces. Examples include the lubrication of articulating joints by synovial fluid, the coating of the lung by pulmonary surfactant and the functions of the tear film in the protection of the anterior eye. The role of the lipids is similar at each site - acting as boundary lubricants and reducing surface and interfacial tension. This review focuses on how and why contact lens wear can disrupt the normal function of lipids within the tear film and explains how the otherwise advantageous presence and function of tear lipids can become disadvantageous, causing problems for the wearer. Because the contact lens is some ten times thicker than the tear film, lipids deposited on the anterior surface become immobilised, reducing lipid turnover and thus leading to prolonged exposure to oxygen and light with consequent generation of degradation products. These degraded lipids reduce lens wettability and have additionally been linked to problems of contact lens discomfort and intolerance. Lipid problems are influenced by the thickness of the lens, the material, surface modification, mode of wear and ultimately the subject. The most influential of these variables is frequently the subject.",
keywords = "contact lens intolerance, lipid oxidation, meibomian gland, tear lipids",
author = "Amandeep Panaser and Tighe, {Brian J.}",
year = "2012",
month = "6",
doi = "10.1016/j.clae.2012.01.003",
language = "English",
volume = "35",
pages = "100--111",
journal = "Contact Lens and Anterior Eye",
issn = "1367-0484",
publisher = "Elsevier",
number = "3",

}

Function of lipids - their fate in contact lens wear : an interpretive review. / Panaser, Amandeep; Tighe, Brian J.

In: Contact Lens and Anterior Eye, Vol. 35, No. 3, 06.2012, p. 100-111.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Function of lipids - their fate in contact lens wear

T2 - an interpretive review

AU - Panaser, Amandeep

AU - Tighe, Brian J.

PY - 2012/6

Y1 - 2012/6

N2 - Lipids play a vital role in the body at many interfaces. Examples include the lubrication of articulating joints by synovial fluid, the coating of the lung by pulmonary surfactant and the functions of the tear film in the protection of the anterior eye. The role of the lipids is similar at each site - acting as boundary lubricants and reducing surface and interfacial tension. This review focuses on how and why contact lens wear can disrupt the normal function of lipids within the tear film and explains how the otherwise advantageous presence and function of tear lipids can become disadvantageous, causing problems for the wearer. Because the contact lens is some ten times thicker than the tear film, lipids deposited on the anterior surface become immobilised, reducing lipid turnover and thus leading to prolonged exposure to oxygen and light with consequent generation of degradation products. These degraded lipids reduce lens wettability and have additionally been linked to problems of contact lens discomfort and intolerance. Lipid problems are influenced by the thickness of the lens, the material, surface modification, mode of wear and ultimately the subject. The most influential of these variables is frequently the subject.

AB - Lipids play a vital role in the body at many interfaces. Examples include the lubrication of articulating joints by synovial fluid, the coating of the lung by pulmonary surfactant and the functions of the tear film in the protection of the anterior eye. The role of the lipids is similar at each site - acting as boundary lubricants and reducing surface and interfacial tension. This review focuses on how and why contact lens wear can disrupt the normal function of lipids within the tear film and explains how the otherwise advantageous presence and function of tear lipids can become disadvantageous, causing problems for the wearer. Because the contact lens is some ten times thicker than the tear film, lipids deposited on the anterior surface become immobilised, reducing lipid turnover and thus leading to prolonged exposure to oxygen and light with consequent generation of degradation products. These degraded lipids reduce lens wettability and have additionally been linked to problems of contact lens discomfort and intolerance. Lipid problems are influenced by the thickness of the lens, the material, surface modification, mode of wear and ultimately the subject. The most influential of these variables is frequently the subject.

KW - contact lens intolerance

KW - lipid oxidation

KW - meibomian gland

KW - tear lipids

UR - http://www.scopus.com/inward/record.url?scp=84860553104&partnerID=8YFLogxK

U2 - 10.1016/j.clae.2012.01.003

DO - 10.1016/j.clae.2012.01.003

M3 - Article

C2 - 22317829

AN - SCOPUS:84860553104

VL - 35

SP - 100

EP - 111

JO - Contact Lens and Anterior Eye

JF - Contact Lens and Anterior Eye

SN - 1367-0484

IS - 3

ER -