Functional Changes in Blood Microcirculation in the Skin of the Foot during Heating Tests in Patients with Diabetes Mellitus

M. A. Filina*, E. V. Potapova, I. N. Makovik, E. V. Zharkih, V. V. Dremin, E. A. Zherebtsov, A. V. Dunaev, V. V. Sidorov, A. I. Krupatkin, E. A. Alimicheva, G. I. Masalygina, V. F. Muradyan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The paper shows the possibility of using the laser Doppler flowmetry method for the assessment of system of blood microcirculation in the lower limbs of patients with diabetes mellitus. A series of experimental studies involving 76 patients with diabetes mellitus and 46 healthy volunteers was carried out. The state of peripheral blood flow was assessed during the local heating tests with different temperature regimes. The wavelet analysis of LDF-grams was used to evaluate the adaptive changes of microcirculation during the temperature tests. The data show that the proposed methodology in the form of heating tests and the use of the wavelet transform in the analysis of LDF-grams allows the evaluation of adaptation processes in the microcirculatory bed during thermal tests and the detection of the preclinical stage of trophic disorders.

Original languageEnglish
Pages (from-to)693-699
Number of pages7
JournalHuman Physiology
Issue number6
Early online date1 Nov 2017
Publication statusPublished - 27 Feb 2018

Bibliographical note

Funding Information:
ACKNOWLEDGMENTS This study was supported by the Grant of the President of the Russian Federation for the State Support of Young Russian Candidates of Sciences (project no. MK-7168.2016.8) and the Russian Foundation for Basic Research (project no. 17-41-590560).

Publisher Copyright:
© 2017, Pleiades Publishing, Inc.

Copyright 2018 Elsevier B.V., All rights reserved.


  • blood microcirculation
  • diabetes mellitus
  • heating test
  • laser Doppler flowmetry
  • noninvasive diagnosis


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