Functional neuroanatomy and behavioural correlates of the basal ganglia

evidence from lesion studies

Peter Ward, Stefano Seri, Andrea Eugenio Cavanna

Research output: Contribution to journalSpecial issue

Abstract

Introduction: The basal ganglia are interconnected with cortical areas involved in behavioural, cognitive and emotional processes, in addition to movement regulation. Little is known about which of these functions are associated with individual basal ganglia substructures. Methods: Pubmed was searched for literature related to behavioural, cognitive and emotional symptoms associated with focal lesions to basal ganglia structures in humans. Results: Six case-control studies and two case reports were identified as relevant. Lesion sites included the caudate nucleus, putamen and globus pallidus. These were associated with a spectrum of behavioural and cognitive symptoms, including abulia, poor working memory and deficits in emotional recognition. Discussion: It is often difficult to precisely map associations between cognitive, emotional or behavioural functions and particular basal ganglia substructures, due to the non-specific nature of the lesions. However, evidence from lesion studies shows that most symptoms correspond with established non-motor frontal-subcortical circuits.

Original languageEnglish
Pages (from-to)219-223
Number of pages5
JournalBehavioural Neurology
Volume26
Issue number4
DOIs
Publication statusPublished - 2013

Fingerprint

Neuroanatomy
Basal Ganglia
Neurobehavioral Manifestations
Behavioral Symptoms
Globus Pallidus
Caudate Nucleus
Putamen
Memory Disorders
Short-Term Memory
PubMed
Case-Control Studies

Bibliographical note

Copyright © 2013 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Keywords

  • basal ganglia
  • behaviour
  • cognition
  • emotion
  • lesion
  • neuropathology

Cite this

@article{be0585a3f9b7479391ca97941cf62086,
title = "Functional neuroanatomy and behavioural correlates of the basal ganglia: evidence from lesion studies",
abstract = "Introduction: The basal ganglia are interconnected with cortical areas involved in behavioural, cognitive and emotional processes, in addition to movement regulation. Little is known about which of these functions are associated with individual basal ganglia substructures. Methods: Pubmed was searched for literature related to behavioural, cognitive and emotional symptoms associated with focal lesions to basal ganglia structures in humans. Results: Six case-control studies and two case reports were identified as relevant. Lesion sites included the caudate nucleus, putamen and globus pallidus. These were associated with a spectrum of behavioural and cognitive symptoms, including abulia, poor working memory and deficits in emotional recognition. Discussion: It is often difficult to precisely map associations between cognitive, emotional or behavioural functions and particular basal ganglia substructures, due to the non-specific nature of the lesions. However, evidence from lesion studies shows that most symptoms correspond with established non-motor frontal-subcortical circuits.",
keywords = "basal ganglia, behaviour, cognition, emotion, lesion, neuropathology",
author = "Peter Ward and Stefano Seri and Cavanna, {Andrea Eugenio}",
note = "Copyright {\circledC} 2013 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.",
year = "2013",
doi = "10.3233/BEN-2012-120264",
language = "English",
volume = "26",
pages = "219--223",
journal = "Behavioural Neurology",
issn = "0953-4180",
publisher = "IOS",
number = "4",

}

Functional neuroanatomy and behavioural correlates of the basal ganglia : evidence from lesion studies. / Ward, Peter; Seri, Stefano; Cavanna, Andrea Eugenio.

In: Behavioural Neurology, Vol. 26, No. 4, 2013, p. 219-223.

Research output: Contribution to journalSpecial issue

TY - JOUR

T1 - Functional neuroanatomy and behavioural correlates of the basal ganglia

T2 - evidence from lesion studies

AU - Ward, Peter

AU - Seri, Stefano

AU - Cavanna, Andrea Eugenio

N1 - Copyright © 2013 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PY - 2013

Y1 - 2013

N2 - Introduction: The basal ganglia are interconnected with cortical areas involved in behavioural, cognitive and emotional processes, in addition to movement regulation. Little is known about which of these functions are associated with individual basal ganglia substructures. Methods: Pubmed was searched for literature related to behavioural, cognitive and emotional symptoms associated with focal lesions to basal ganglia structures in humans. Results: Six case-control studies and two case reports were identified as relevant. Lesion sites included the caudate nucleus, putamen and globus pallidus. These were associated with a spectrum of behavioural and cognitive symptoms, including abulia, poor working memory and deficits in emotional recognition. Discussion: It is often difficult to precisely map associations between cognitive, emotional or behavioural functions and particular basal ganglia substructures, due to the non-specific nature of the lesions. However, evidence from lesion studies shows that most symptoms correspond with established non-motor frontal-subcortical circuits.

AB - Introduction: The basal ganglia are interconnected with cortical areas involved in behavioural, cognitive and emotional processes, in addition to movement regulation. Little is known about which of these functions are associated with individual basal ganglia substructures. Methods: Pubmed was searched for literature related to behavioural, cognitive and emotional symptoms associated with focal lesions to basal ganglia structures in humans. Results: Six case-control studies and two case reports were identified as relevant. Lesion sites included the caudate nucleus, putamen and globus pallidus. These were associated with a spectrum of behavioural and cognitive symptoms, including abulia, poor working memory and deficits in emotional recognition. Discussion: It is often difficult to precisely map associations between cognitive, emotional or behavioural functions and particular basal ganglia substructures, due to the non-specific nature of the lesions. However, evidence from lesion studies shows that most symptoms correspond with established non-motor frontal-subcortical circuits.

KW - basal ganglia

KW - behaviour

KW - cognition

KW - emotion

KW - lesion

KW - neuropathology

UR - http://www.scopus.com/inward/record.url?scp=84876219886&partnerID=8YFLogxK

U2 - 10.3233/BEN-2012-120264

DO - 10.3233/BEN-2012-120264

M3 - Special issue

VL - 26

SP - 219

EP - 223

JO - Behavioural Neurology

JF - Behavioural Neurology

SN - 0953-4180

IS - 4

ER -