Functional proteomics to dissect tyrosine kinase signalling pathways in cancer

Walter Kolch, Andrew Pitt

Research output: Contribution to journalReview article

Abstract

Advances in the generation and interpretation of proteomics data have spurred a transition from focusing on protein identification to functional analysis. Here we review recent proteomics results that have elucidated new aspects of the roles and regulation of signal transduction pathways in cancer using the epidermal growth factor receptor (EGFR), ERK and breakpoint cluster region (BCR)-ABL1 networks as examples. The emerging theme is to understand cancer signalling as networks of multiprotein machines which process information in a highly dynamic environment that is shaped by changing protein interactions and post-translational modifications (PTMs). Cancerous genetic mutations derange these protein networks in complex ways that are tractable by proteomics.
Original languageEnglish
Pages (from-to)618-629
Number of pages12
JournalNature Reviews: Cancer
Volume10
Issue number9
DOIs
Publication statusPublished - Sep 2010

Bibliographical note

Copyright © 2010, Springer Nature

Keywords

  • animals
  • humans
  • neoplasms
  • protein binding
  • post-translational protein processing
  • protein-tyrosine kinases
  • proteomics
  • signal transduction

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