Functionalised solids delivering bioactive nitric oxide gas for therapeutic applications

Sharon T. Gregg, Qingchun Yuan, Russell E. Morris, Bo Xiao*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

It is well established that nitric oxide is an effective vasodilative, antibacterial and tumoricidal agent, however its targeted delivery in a controllable manner is challenging but necessary for successful therapeutic applications. In recent years a few new methods have been developed, based on the formation of N-diazeniumdiolates, S-nitrosothiols and metal [sbnd]NO coordination bonds in material structures. The typical delivery materials include nanoporous materials (such as zeolites and metal organic frameworks), silicate particles and polymers containing amine and thiol functional groups. These materials are of promising potential for delivering controllable doses of bioactive NO gas to meet the unmet therapeutic needs in the future. This review summarises these delivery materials and relevant biological assessments. Further improvement of current methods and new design of NO donors are still required in order to address the issues on NO storage and its release profile in matching with the clinical requirements.

Original languageEnglish
Pages (from-to)95-105
Number of pages11
JournalMaterials Today Communications
Volume12
Early online date31 Jul 2017
DOIs
Publication statusPublished - Sep 2017

Bibliographical note

© 2017, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/

Funding: EPSRC (EP/M027295/1).

Keywords

  • antomicrobials
  • drug delivery
  • metal organic framework
  • nitric oxide
  • nitric oxide biological function
  • zeolite

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