Functionalised solids delivering bioactive nitric oxide gas for therapeutic applications

Sharon T. Gregg, Qingchun Yuan, Russell E. Morris, Bo Xiao

Research output: Contribution to journalArticle

Abstract

It is well established that nitric oxide is an effective vasodilative, antibacterial and tumoricidal agent, however its targeted delivery in a controllable manner is challenging but necessary for successful therapeutic applications. In recent years a few new methods have been developed, based on the formation of N-diazeniumdiolates, S-nitrosothiols and metal [sbnd]NO coordination bonds in material structures. The typical delivery materials include nanoporous materials (such as zeolites and metal organic frameworks), silicate particles and polymers containing amine and thiol functional groups. These materials are of promising potential for delivering controllable doses of bioactive NO gas to meet the unmet therapeutic needs in the future. This review summarises these delivery materials and relevant biological assessments. Further improvement of current methods and new design of NO donors are still required in order to address the issues on NO storage and its release profile in matching with the clinical requirements.

Original languageEnglish
Pages (from-to)95-105
Number of pages11
JournalMaterials Today Communications
Volume12
Early online date31 Jul 2017
DOIs
Publication statusPublished - Sep 2017

Fingerprint

Nitric oxide
Nitric Oxide
Gases
Metals
S-Nitrosothiols
Zeolites
Silicates
Sulfhydryl Compounds
Functional groups
Amines
Polymers

Bibliographical note

© 2017, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/

Funding: EPSRC (EP/M027295/1).

Keywords

  • antomicrobials
  • drug delivery
  • metal organic framework
  • nitric oxide
  • nitric oxide biological function
  • zeolite

Cite this

Gregg, Sharon T. ; Yuan, Qingchun ; Morris, Russell E. ; Xiao, Bo. / Functionalised solids delivering bioactive nitric oxide gas for therapeutic applications. In: Materials Today Communications. 2017 ; Vol. 12. pp. 95-105.
@article{66767180758149ada3cb3b8244fdf3d2,
title = "Functionalised solids delivering bioactive nitric oxide gas for therapeutic applications",
abstract = "It is well established that nitric oxide is an effective vasodilative, antibacterial and tumoricidal agent, however its targeted delivery in a controllable manner is challenging but necessary for successful therapeutic applications. In recent years a few new methods have been developed, based on the formation of N-diazeniumdiolates, S-nitrosothiols and metal [sbnd]NO coordination bonds in material structures. The typical delivery materials include nanoporous materials (such as zeolites and metal organic frameworks), silicate particles and polymers containing amine and thiol functional groups. These materials are of promising potential for delivering controllable doses of bioactive NO gas to meet the unmet therapeutic needs in the future. This review summarises these delivery materials and relevant biological assessments. Further improvement of current methods and new design of NO donors are still required in order to address the issues on NO storage and its release profile in matching with the clinical requirements.",
keywords = "antomicrobials, drug delivery, metal organic framework, nitric oxide, nitric oxide biological function, zeolite",
author = "Gregg, {Sharon T.} and Qingchun Yuan and Morris, {Russell E.} and Bo Xiao",
note = "{\circledC} 2017, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ Funding: EPSRC (EP/M027295/1).",
year = "2017",
month = "9",
doi = "10.1016/j.mtcomm.2017.07.007",
language = "English",
volume = "12",
pages = "95--105",

}

Gregg, ST, Yuan, Q, Morris, RE & Xiao, B 2017, 'Functionalised solids delivering bioactive nitric oxide gas for therapeutic applications', Materials Today Communications, vol. 12, pp. 95-105. https://doi.org/10.1016/j.mtcomm.2017.07.007

Functionalised solids delivering bioactive nitric oxide gas for therapeutic applications. / Gregg, Sharon T.; Yuan, Qingchun; Morris, Russell E.; Xiao, Bo.

In: Materials Today Communications, Vol. 12, 09.2017, p. 95-105.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Functionalised solids delivering bioactive nitric oxide gas for therapeutic applications

AU - Gregg, Sharon T.

AU - Yuan, Qingchun

AU - Morris, Russell E.

AU - Xiao, Bo

N1 - © 2017, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ Funding: EPSRC (EP/M027295/1).

PY - 2017/9

Y1 - 2017/9

N2 - It is well established that nitric oxide is an effective vasodilative, antibacterial and tumoricidal agent, however its targeted delivery in a controllable manner is challenging but necessary for successful therapeutic applications. In recent years a few new methods have been developed, based on the formation of N-diazeniumdiolates, S-nitrosothiols and metal [sbnd]NO coordination bonds in material structures. The typical delivery materials include nanoporous materials (such as zeolites and metal organic frameworks), silicate particles and polymers containing amine and thiol functional groups. These materials are of promising potential for delivering controllable doses of bioactive NO gas to meet the unmet therapeutic needs in the future. This review summarises these delivery materials and relevant biological assessments. Further improvement of current methods and new design of NO donors are still required in order to address the issues on NO storage and its release profile in matching with the clinical requirements.

AB - It is well established that nitric oxide is an effective vasodilative, antibacterial and tumoricidal agent, however its targeted delivery in a controllable manner is challenging but necessary for successful therapeutic applications. In recent years a few new methods have been developed, based on the formation of N-diazeniumdiolates, S-nitrosothiols and metal [sbnd]NO coordination bonds in material structures. The typical delivery materials include nanoporous materials (such as zeolites and metal organic frameworks), silicate particles and polymers containing amine and thiol functional groups. These materials are of promising potential for delivering controllable doses of bioactive NO gas to meet the unmet therapeutic needs in the future. This review summarises these delivery materials and relevant biological assessments. Further improvement of current methods and new design of NO donors are still required in order to address the issues on NO storage and its release profile in matching with the clinical requirements.

KW - antomicrobials

KW - drug delivery

KW - metal organic framework

KW - nitric oxide

KW - nitric oxide biological function

KW - zeolite

UR - http://www.scopus.com/inward/record.url?scp=85026890954&partnerID=8YFLogxK

U2 - 10.1016/j.mtcomm.2017.07.007

DO - 10.1016/j.mtcomm.2017.07.007

M3 - Article

VL - 12

SP - 95

EP - 105

ER -