Further studies on the patterns of senile plaques in senile dementia of the Alzheimer type (SDAT) with a hypothesis on the colonization of the cortex

Richard A. Armstrong, D. Myers, C.U.M. Smith

Research output: Contribution to journalArticle

Abstract

The pattern of senile plaques was investigated in various brain regions of six SDAT brains. In 91 pattern analyses, the regularly spaced clump was the most common pattern found in 64.8% of analyses. Clumping due to large aggregations of uncored plaques in sulci was also common. Regularly spaced clumps were equally common in the hippocampus and neocortex. The pattern of plaques varied in different tissue sections from the same brain region. Cored and uncored plaques presented a similar range of patterns but their pattern varied when they were both present in the same tissue section. Both clump diameter and the intensity of clumping were positively correlated with cored but unrelated to uncored plaque density. Plaques may develop in regular clumps on subcortical afferents and during development of the disease the clumps may spread laterally and ultimately coalesce.
Original languageEnglish
Pages (from-to)17-24
Number of pages8
JournalNeuroscience Research Communications
Volume4
Issue number1
Publication statusPublished - 1989

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Amyloid Plaques
Alzheimer Disease
Brain
Neocortex
Hippocampus

Keywords

  • plaques
  • pattern
  • columns
  • subcortical afferents
  • colonization

Cite this

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Further studies on the patterns of senile plaques in senile dementia of the Alzheimer type (SDAT) with a hypothesis on the colonization of the cortex. / Armstrong, Richard A.; Myers, D.; Smith, C.U.M.

In: Neuroscience Research Communications, Vol. 4, No. 1, 1989, p. 17-24.

Research output: Contribution to journalArticle

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