GABA(A) alpha-1 subunit mediated desynchronization of elevated low frequency oscillations alleviates specific dysfunction in stroke: a case report

Stephen Hall, Naoki Yamawaki, Alison Fisher, Ralf Clauss, Gavin Woodhall, Ian Stanford

Research output: Contribution to journalArticle

Abstract

The paradoxical effects of the hypnotic imidazopyridine zolpidem, widely reported in persistent vegetative state, have been replicated recently in brain-injured and cognitively impaired patients. However, the neuronal mechanisms underlying these benefits are yet to be demonstrated. We implemented contemporary neuroimaging methods to investigate sensorimotor and cognitive improvements, observed in stroke patient JP following zolpidem administration.
LanguageEnglish
Article number20097125
Pages549-555
Number of pages6
JournalClinical Neurophysiology
Volume121
Issue number4
Early online date25 Jan 2010
DOIs
Publication statusPublished - 12 Apr 2010

Fingerprint

gamma-Aminobutyric Acid
Stroke
Persistent Vegetative State
Hypnotics and Sedatives
Neuroimaging
Brain
zolpidem

Keywords

  • magnetoencephalography
  • GABA
  • MEG
  • theta
  • beta
  • stroke
  • pathological oscillations

Cite this

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GABA(A) alpha-1 subunit mediated desynchronization of elevated low frequency oscillations alleviates specific dysfunction in stroke : a case report. / Hall, Stephen; Yamawaki, Naoki; Fisher, Alison; Clauss, Ralf; Woodhall, Gavin; Stanford, Ian.

In: Clinical Neurophysiology , Vol. 121, No. 4, 20097125, 12.04.2010, p. 549-555.

Research output: Contribution to journalArticle

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