GABA(A) alpha-1 subunit mediated desynchronization of elevated low frequency oscillations alleviates specific dysfunction in stroke: a case report

Stephen Hall; Naoki Yamawaki; Alison Fisher; Ralf Clauss; Gavin Woodhall; Ian Stanford

doi:10.1016/j.clinph.2009.11.084

GABA(A) alpha-1 subunit mediated desynchronization of elevated low frequency oscillations alleviates specific dysfunction in stroke: a case report

Stephen Hall
, Naoki Yamawaki
, Alison Fisher
, Ralf Clauss
, Gavin Woodhall
, Ian Stanford

Surrey and Hampshire Borders NHS Trust

Research output: Contribution to journal › Article › peer-review

75 Citations (SciVal)

Abstract

The paradoxical effects of the hypnotic imidazopyridine zolpidem, widely reported in persistent vegetative state, have been replicated recently in brain-injured and cognitively impaired patients. However, the neuronal mechanisms underlying these benefits are yet to be demonstrated. We implemented contemporary neuroimaging methods to investigate sensorimotor and cognitive improvements, observed in stroke patient JP following zolpidem administration.

Original language	English
Article number	20097125
Pages (from-to)	549-555
Number of pages	6
Journal	Clinical Neurophysiology
Volume	121
Issue number	4
Early online date	25 Jan 2010
DOIs	https://doi.org/10.1016/j.clinph.2009.11.084
Publication status	Published - 12 Apr 2010

Keywords

magnetoencephalography
GABA
MEG
theta
beta
stroke
pathological oscillations

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10.1016/j.clinph.2009.11.084

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AU - Clauss, Ralf

AU - Woodhall, Gavin

AU - Stanford, Ian

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KW - magnetoencephalography

KW - GABA

KW - MEG

KW - theta

KW - beta

KW - stroke

KW - pathological oscillations

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GABA(A) alpha-1 subunit mediated desynchronization of elevated low frequency oscillations alleviates specific dysfunction in stroke: a case report

Abstract

Keywords

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