TY - JOUR
T1 - Gene therapy strategies for the treatment of spinal cord injury
AU - Uchida, Kenzo
AU - Nakajima, Hideaki
AU - Guerrero, Alexander Rodriguez
AU - Johnson, William Eb
AU - El Masri, Wagih
AU - Baba, Hisatoshi
PY - 2014
Y1 - 2014
N2 - Spinal cord injury is a complex pathology often resulting in functional impairment and paralysis. Gene therapy has emerged as a possible solution to the problems of limited neural tissue regeneration through the administration of factors promoting axonal growth, while also offering long-term local delivery of therapeutic molecules at the injury site. Of note, gene therapy is our response to the requirements of neural and glial cells following spinal cord injury, providing, in a time-dependent manner, growth substances for axonal regeneration and eliminating axonal growth inhibitors. Herein, we explore different gene therapy strategies, including targeting gene expression to modulate the presence of neurotrophic growth or survival factors and increase neural tissue plasticity. Special attention is given to describing advances in viral and non-viral gene delivery systems, as well as the available routes of gene delivery. Finally, we discuss the future of combinatorial gene therapies and give consideration to the implementation of gene therapy in humans.
AB - Spinal cord injury is a complex pathology often resulting in functional impairment and paralysis. Gene therapy has emerged as a possible solution to the problems of limited neural tissue regeneration through the administration of factors promoting axonal growth, while also offering long-term local delivery of therapeutic molecules at the injury site. Of note, gene therapy is our response to the requirements of neural and glial cells following spinal cord injury, providing, in a time-dependent manner, growth substances for axonal regeneration and eliminating axonal growth inhibitors. Herein, we explore different gene therapy strategies, including targeting gene expression to modulate the presence of neurotrophic growth or survival factors and increase neural tissue plasticity. Special attention is given to describing advances in viral and non-viral gene delivery systems, as well as the available routes of gene delivery. Finally, we discuss the future of combinatorial gene therapies and give consideration to the implementation of gene therapy in humans.
UR - http://www.scopus.com/inward/record.url?scp=84903993216&partnerID=8YFLogxK
U2 - 10.4155/tde.14.20
DO - 10.4155/tde.14.20
M3 - Article
C2 - 24998276
AN - SCOPUS:84903993216
SN - 2041-5990
VL - 5
SP - 591
EP - 607
JO - Therapeutic Delivery
JF - Therapeutic Delivery
IS - 5
ER -