Generation of the maternal low-protein rat model for studies of metabolic disorders

Dan Ma, Susan E. Ozanne, Paul C. Guest*

*Corresponding author for this work

Research output: Chapter in Book/Published conference outputChapter


Poor nutrition during pregnancy leads to an increased risk of metabolic disorders and other diseases in the offspring. This can be modelled in animals through manipulation of the maternal diet. One such model is the maternal low-protein rat which gives rise to offspring characterized by insulin resistance. This chapter gives a detailed protocol for generation of the maternal low-protein rat, which has been used in the study of several disorders including diabetes and psychiatric disorders.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
EditorsP. Guest
PublisherHumana Press
Number of pages6
ISBN (Electronic)978-1-4939-7614-0
ISBN (Print)978-1-4939-7613-3
Publication statusPublished - 30 Jan 2018

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745


  • Biomarkers
  • Diabetes
  • Insulin resistance
  • Low-protein rat
  • Metabolic programming
  • Psychiatric disorders


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