Generation of the maternal low-protein rat model for studies of metabolic disorders

Dan Ma; Susan E. Ozanne; Paul C. Guest

doi:10.1007/978-1-4939-7614-0_10

Generation of the maternal low-protein rat model for studies of metabolic disorders

Dan Ma
, Susan E. Ozanne
, Paul C. Guest^*

^*Corresponding author for this work

University of Cambridge
Addenbrooke’s Hospital
Universidade Estadual de Campinas

Research output: Chapter in Book/Published conference output › Chapter

1 Citation (Scopus)

Abstract

Poor nutrition during pregnancy leads to an increased risk of metabolic disorders and other diseases in the offspring. This can be modelled in animals through manipulation of the maternal diet. One such model is the maternal low-protein rat which gives rise to offspring characterized by insulin resistance. This chapter gives a detailed protocol for generation of the maternal low-protein rat, which has been used in the study of several disorders including diabetes and psychiatric disorders.

Original language	English
Title of host publication	Methods in Molecular Biology
Editors	P. Guest
Publisher	Humana Press
Pages	201-206
Number of pages	6
ISBN (Electronic)	978-1-4939-7614-0
ISBN (Print)	978-1-4939-7613-3
DOIs	https://doi.org/10.1007/978-1-4939-7614-0_10
Publication status	Published - 30 Jan 2018

Publication series

Name	Methods in Molecular Biology
Volume	1735
ISSN (Print)	1064-3745

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Biomarkers
Diabetes
Insulin resistance
Low-protein rat
Metabolic programming
Psychiatric disorders

Access to Document

10.1007/978-1-4939-7614-0_10

https://www.repository.cam.ac.uk/handle/1810/276414

Cite this

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title = "Generation of the maternal low-protein rat model for studies of metabolic disorders",

abstract = "Poor nutrition during pregnancy leads to an increased risk of metabolic disorders and other diseases in the offspring. This can be modelled in animals through manipulation of the maternal diet. One such model is the maternal low-protein rat which gives rise to offspring characterized by insulin resistance. This chapter gives a detailed protocol for generation of the maternal low-protein rat, which has been used in the study of several disorders including diabetes and psychiatric disorders.",

keywords = "Biomarkers, Diabetes, Insulin resistance, Low-protein rat, Metabolic programming, Psychiatric disorders",

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AU - Ozanne, Susan E.

AU - Guest, Paul C.

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N2 - Poor nutrition during pregnancy leads to an increased risk of metabolic disorders and other diseases in the offspring. This can be modelled in animals through manipulation of the maternal diet. One such model is the maternal low-protein rat which gives rise to offspring characterized by insulin resistance. This chapter gives a detailed protocol for generation of the maternal low-protein rat, which has been used in the study of several disorders including diabetes and psychiatric disorders.

AB - Poor nutrition during pregnancy leads to an increased risk of metabolic disorders and other diseases in the offspring. This can be modelled in animals through manipulation of the maternal diet. One such model is the maternal low-protein rat which gives rise to offspring characterized by insulin resistance. This chapter gives a detailed protocol for generation of the maternal low-protein rat, which has been used in the study of several disorders including diabetes and psychiatric disorders.

KW - Biomarkers

KW - Diabetes

KW - Insulin resistance

KW - Low-protein rat

KW - Metabolic programming

KW - Psychiatric disorders

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BT - Methods in Molecular Biology

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PB - Humana Press

ER -

Generation of the maternal low-protein rat model for studies of metabolic disorders

Abstract

Publication series

UN SDGs

Keywords

Access to Document

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