Ghrelin receptor gene polymorphisms and body size in children and adults

Edwin A Garcia; Barbara Heude; Clive J Petry; Maria Gueorguiev; Zaki K Hassan-Smith; Antigoni Spanou; Susan M Ring; David B Dunger; Nicholas Wareham; Manjinder S Sandhu; Ken K Ong; Márta Korbonits

doi:10.1210/jc.2008-0366

Ghrelin receptor gene polymorphisms and body size in children and adults

Edwin A Garcia, Barbara Heude, Clive J Petry, Maria Gueorguiev, Zaki K Hassan-Smith, Antigoni Spanou, Susan M Ring, David B Dunger, Nicholas Wareham, Manjinder S Sandhu, Ken K Ong, Márta Korbonits

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: The GH secretagogue receptor type 1a gene (GHSR) encodes the cognate receptor of ghrelin, a gut hormone that regulates food intake and pituitary GH secretion. Previous studies in U.S. families and a German population suggested GHSR to be a candidate quantitative locus for association with human obesity and growth.

AIM: The aim of the study was to test common genetic variation in GHSR for association with body size in children and adults.

METHODS: Sequencing was performed to systematically identify novel single nucleotide polymorphisms (SNPs) in GHSR. A set of three haplotype-tagging SNPs that captured all the genetic variation in GHSR was identified. These three haplotype-tagging SNPs were then genotyped in three large population-based U.K. cohort studies (two adult and one childhood cohort) comprising 5807 adults and 843 children.

RESULTS: No significant genotype or haplotype associations were found with adult or childhood height, weight, or body mass index.

CONCLUSION: Common variation in GHSR is not associated with body size in U.K. adults or children.

Original language	English
Pages (from-to)	4158-4161
Number of pages	4
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	93
Issue number	10
DOIs	https://doi.org/10.1210/jc.2008-0366
Publication status	Published - Oct 2008

Keywords

Adult
Aged
Body Size/genetics
Child
Child, Preschool
Cohort Studies
DNA Mutational Analysis
Female
Gene Frequency
Genotype
Humans
Infant
Linkage Disequilibrium
Male
Middle Aged
Polymorphism, Single Nucleotide
Receptors, Ghrelin/genetics
United Kingdom

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title = "Ghrelin receptor gene polymorphisms and body size in children and adults",

abstract = "BACKGROUND: The GH secretagogue receptor type 1a gene (GHSR) encodes the cognate receptor of ghrelin, a gut hormone that regulates food intake and pituitary GH secretion. Previous studies in U.S. families and a German population suggested GHSR to be a candidate quantitative locus for association with human obesity and growth.AIM: The aim of the study was to test common genetic variation in GHSR for association with body size in children and adults.METHODS: Sequencing was performed to systematically identify novel single nucleotide polymorphisms (SNPs) in GHSR. A set of three haplotype-tagging SNPs that captured all the genetic variation in GHSR was identified. These three haplotype-tagging SNPs were then genotyped in three large population-based U.K. cohort studies (two adult and one childhood cohort) comprising 5807 adults and 843 children.RESULTS: No significant genotype or haplotype associations were found with adult or childhood height, weight, or body mass index.CONCLUSION: Common variation in GHSR is not associated with body size in U.K. adults or children.",

keywords = "Adult, Aged, Body Size/genetics, Child, Child, Preschool, Cohort Studies, DNA Mutational Analysis, Female, Gene Frequency, Genotype, Humans, Infant, Linkage Disequilibrium, Male, Middle Aged, Polymorphism, Single Nucleotide, Receptors, Ghrelin/genetics, United Kingdom",

author = "Garcia, {Edwin A} and Barbara Heude and Petry, {Clive J} and Maria Gueorguiev and Hassan-Smith, {Zaki K} and Antigoni Spanou and Ring, {Susan M} and Dunger, {David B} and Nicholas Wareham and Sandhu, {Manjinder S} and Ong, {Ken K} and M{\'a}rta Korbonits",

year = "2008",

month = oct,

doi = "10.1210/jc.2008-0366",

language = "English",

volume = "93",

pages = "4158--4161",

journal = "Journal of Clinical Endocrinology and Metabolism ",

issn = "0021-972X",

publisher = "The Endocrine Society",

number = "10",

}

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T1 - Ghrelin receptor gene polymorphisms and body size in children and adults

AU - Garcia, Edwin A

AU - Heude, Barbara

AU - Petry, Clive J

AU - Gueorguiev, Maria

AU - Hassan-Smith, Zaki K

AU - Spanou, Antigoni

AU - Ring, Susan M

AU - Dunger, David B

AU - Wareham, Nicholas

AU - Sandhu, Manjinder S

AU - Ong, Ken K

AU - Korbonits, Márta

PY - 2008/10

Y1 - 2008/10

N2 - BACKGROUND: The GH secretagogue receptor type 1a gene (GHSR) encodes the cognate receptor of ghrelin, a gut hormone that regulates food intake and pituitary GH secretion. Previous studies in U.S. families and a German population suggested GHSR to be a candidate quantitative locus for association with human obesity and growth.AIM: The aim of the study was to test common genetic variation in GHSR for association with body size in children and adults.METHODS: Sequencing was performed to systematically identify novel single nucleotide polymorphisms (SNPs) in GHSR. A set of three haplotype-tagging SNPs that captured all the genetic variation in GHSR was identified. These three haplotype-tagging SNPs were then genotyped in three large population-based U.K. cohort studies (two adult and one childhood cohort) comprising 5807 adults and 843 children.RESULTS: No significant genotype or haplotype associations were found with adult or childhood height, weight, or body mass index.CONCLUSION: Common variation in GHSR is not associated with body size in U.K. adults or children.

AB - BACKGROUND: The GH secretagogue receptor type 1a gene (GHSR) encodes the cognate receptor of ghrelin, a gut hormone that regulates food intake and pituitary GH secretion. Previous studies in U.S. families and a German population suggested GHSR to be a candidate quantitative locus for association with human obesity and growth.AIM: The aim of the study was to test common genetic variation in GHSR for association with body size in children and adults.METHODS: Sequencing was performed to systematically identify novel single nucleotide polymorphisms (SNPs) in GHSR. A set of three haplotype-tagging SNPs that captured all the genetic variation in GHSR was identified. These three haplotype-tagging SNPs were then genotyped in three large population-based U.K. cohort studies (two adult and one childhood cohort) comprising 5807 adults and 843 children.RESULTS: No significant genotype or haplotype associations were found with adult or childhood height, weight, or body mass index.CONCLUSION: Common variation in GHSR is not associated with body size in U.K. adults or children.

KW - Adult

KW - Aged

KW - Body Size/genetics

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KW - Child, Preschool

KW - Cohort Studies

KW - DNA Mutational Analysis

KW - Female

KW - Gene Frequency

KW - Genotype

KW - Humans

KW - Infant

KW - Linkage Disequilibrium

KW - Male

KW - Middle Aged

KW - Polymorphism, Single Nucleotide

KW - Receptors, Ghrelin/genetics

KW - United Kingdom

UR - https://academic.oup.com/jcem/article/93/10/4158/2627416

U2 - 10.1210/jc.2008-0366

DO - 10.1210/jc.2008-0366

M3 - Article

C2 - 18647811

SN - 0021-972X

VL - 93

SP - 4158

EP - 4161

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

IS - 10

ER -

Ghrelin receptor gene polymorphisms and body size in children and adults

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