Gilles de la Tourette syndrome and disruptive behavior disorders: prevalence, associations, and explanation of the relationships

Mary M. Robertson, Andrea E. Cavanna, Valsamma Eapen*

*Corresponding author for this work

    Research output: Contribution to journalArticle

    Abstract

    Gilles de la Tourette syndrome and conduct disorder (CD) are both heterogeneous childhood onset conditions, and although patients with CD have been described in Gilles de la Tourette syndrome cohorts, little is known about the etiology of CD in Gilles de la Tourette syndrome or of the interrelationships. A cohort of 578 consecutive patients with Gilles de la Tourette syndrome was assessed using standard assessment protocols. A total of 13.5% of participants had only Gilles de la Tourette syndrome, whereas the rest had associated comorbidities and psychopathology. CD occurred in 14.5% of Gilles de la Tourette syndrome probands. These findings suggest that CD is not an integral part of Gilles de la Tourette syndrome but rather that CD in the context of Gilles de la Tourette syndrome is related to the presence of attention deficit hyperactivity disorder, as well as, and importantly, a family history of aggressive and violent behavior and forensic encounters.

    Original languageEnglish
    Pages (from-to)33-41
    Number of pages9
    JournalJournal of Neuropsychiatry and Clinical Neurosciences
    Volume27
    Issue number1
    DOIs
    Publication statusPublished - 2015

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    Attention Deficit and Disruptive Behavior Disorders
    Tourette Syndrome
    Conduct Disorder
    Attention Deficit Disorder with Hyperactivity
    Psychopathology
    Comorbidity

    Cite this

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    abstract = "Gilles de la Tourette syndrome and conduct disorder (CD) are both heterogeneous childhood onset conditions, and although patients with CD have been described in Gilles de la Tourette syndrome cohorts, little is known about the etiology of CD in Gilles de la Tourette syndrome or of the interrelationships. A cohort of 578 consecutive patients with Gilles de la Tourette syndrome was assessed using standard assessment protocols. A total of 13.5{\%} of participants had only Gilles de la Tourette syndrome, whereas the rest had associated comorbidities and psychopathology. CD occurred in 14.5{\%} of Gilles de la Tourette syndrome probands. These findings suggest that CD is not an integral part of Gilles de la Tourette syndrome but rather that CD in the context of Gilles de la Tourette syndrome is related to the presence of attention deficit hyperactivity disorder, as well as, and importantly, a family history of aggressive and violent behavior and forensic encounters.",
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    Gilles de la Tourette syndrome and disruptive behavior disorders : prevalence, associations, and explanation of the relationships. / Robertson, Mary M.; Cavanna, Andrea E.; Eapen, Valsamma.

    In: Journal of Neuropsychiatry and Clinical Neurosciences, Vol. 27, No. 1, 2015, p. 33-41.

    Research output: Contribution to journalArticle

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    AU - Robertson, Mary M.

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    AU - Eapen, Valsamma

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    AB - Gilles de la Tourette syndrome and conduct disorder (CD) are both heterogeneous childhood onset conditions, and although patients with CD have been described in Gilles de la Tourette syndrome cohorts, little is known about the etiology of CD in Gilles de la Tourette syndrome or of the interrelationships. A cohort of 578 consecutive patients with Gilles de la Tourette syndrome was assessed using standard assessment protocols. A total of 13.5% of participants had only Gilles de la Tourette syndrome, whereas the rest had associated comorbidities and psychopathology. CD occurred in 14.5% of Gilles de la Tourette syndrome probands. These findings suggest that CD is not an integral part of Gilles de la Tourette syndrome but rather that CD in the context of Gilles de la Tourette syndrome is related to the presence of attention deficit hyperactivity disorder, as well as, and importantly, a family history of aggressive and violent behavior and forensic encounters.

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