Glycaemic memory

Clifford J. Bailey, Caroline Day

Research output: Contribution to journalArticlepeer-review

Abstract

Glycaemic memory describes the deferred effects of prior glycaemic status on diabetic complications later in life, independent of more recent glycaemic control. Prospective evidence for glycaemic memory derives from extended studies after trials that compared intensive versus standard glycaemic control. These studies in type 1 diabetes (e.g. DCCT) and type 2 diabetes (e.g. UKPDS) have shown that a period of poor glycaemic control earlier in the course of the disease is associated with an increased burden of complications much later in the course of the disease, even when glycaemic control is latterly improved. The Veterans Affairs Diabetes Trial suggested that more than 12-15 years of poor control in older type 2 patients minimised the benefits of subsequently improved glycaemic control. The delayed adverse effects of hyperglycaemia emphasise the importance of effective early glycaemic control.
Original languageEnglish
Pages (from-to)242-247
Number of pages6
JournalBritish Journal of Diabetes and Vascular Disease
Volume8
Issue number5
DOIs
Publication statusPublished - Sep 2008

Keywords

  • glycaemic memory
  • hyperglycaemic memory
  • intensive
  • glycaemic control

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