GPCR modulation by RAMPs

Debbie L. Hay, David R. Poyner, Patrick M. Sexton*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Our conceptual understanding of the molecular architecture of G-protein coupled receptors (GPCRs) has transformed over the last decade. Once considered as largely independent functional units (aside from their interaction with the G-protein itself), it is now clear that a single GPCR is but part of a multifaceted signaling complex, each component providing an additional layer of sophistication. Receptor activity-modifying proteins (RAMPs) provide a notable example of proteins that interact with GPCRs to modify their function. They act as pharmacological switches, modifying GPCR pharmacology for a particular subset of receptors. However, there is accumulating evidence that these ubiquitous proteins have a broader role, regulating signaling and receptor trafficking. This article aims to provide the reader with a comprehensive appraisal of RAMP literature and perhaps some insight into the impact that their discovery has had on those who study GPCRs. © 2005 Elsevier Inc. All rights reserved.

Original languageEnglish
Pages (from-to)173-197
Number of pages25
JournalPharmacology and Therapeutics
Issue number1-2
Publication statusPublished - 12 Jan 2006


  • calcitonin receptor
  • CL receptor
  • family B GPCR
  • GPCR
  • RAMP
  • VPAC1 receptor


Dive into the research topics of 'GPCR modulation by RAMPs'. Together they form a unique fingerprint.

Cite this