Abstract
Our conceptual understanding of the molecular architecture of G-protein coupled receptors (GPCRs) has transformed over the last decade. Once considered as largely independent functional units (aside from their interaction with the G-protein itself), it is now clear that a single GPCR is but part of a multifaceted signaling complex, each component providing an additional layer of sophistication. Receptor activity-modifying proteins (RAMPs) provide a notable example of proteins that interact with GPCRs to modify their function. They act as pharmacological switches, modifying GPCR pharmacology for a particular subset of receptors. However, there is accumulating evidence that these ubiquitous proteins have a broader role, regulating signaling and receptor trafficking. This article aims to provide the reader with a comprehensive appraisal of RAMP literature and perhaps some insight into the impact that their discovery has had on those who study GPCRs. © 2005 Elsevier Inc. All rights reserved.
Original language | English |
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Pages (from-to) | 173-197 |
Number of pages | 25 |
Journal | Pharmacology and Therapeutics |
Volume | 109 |
Issue number | 1-2 |
DOIs | |
Publication status | Published - 12 Jan 2006 |
Keywords
- calcitonin receptor
- CL receptor
- family B GPCR
- GPCR
- RAMP
- VPAC1 receptor