G protein-coupled receptors (GPCRs) play important physiological roles transducing extracellular signals into intracellular responses. Approximately 50% of all marketed drugs target a GPCR. There remains considerable interest in effectively predicting the function of a GPCR from its primary sequence.
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Davies, M. N., Secker, A., Halling-Brown, M., Moss, D. S., Freitas, A. A., Timmis, J., Clark, E., & Flower, D. R. (2008). GPCRTree: online hierarchical classification of GPCR function. BMC Research Notes, 1, 67. . https://doi.org/10.1186/1756-0500-1-67