H3PW12O40/SBA-15 for the Solventless Synthesis of 3-Substituted Indoles

Reza Tayebee, Adam Lee, Lucia Frattini, Shahrebano Rostami

Research output: Contribution to journalArticle

Abstract

A family of silica-supported H3PW12O40 (HPW) solid acid catalysts was prepared by wet impregnation of mesoporous SBA-15 and investigated for the solventless synthesis of 3-substituted indoles under mild conditions. Mesoporous SBA-15 facilitated a high dispersion of immobilised H3PW12O40, significantly improving the catalytic efficiency of the heteropolyacid for the desired multi-component transformation. The yield of 3-substituted indoles strongly correlated with HPW loading (which spanned 3.2–51.6 wt %) and corresponding acid strength; the 51.6 wt % HPW/SBA-15 delivered 81% yield of 2-[(1H-indol-3-yl)(phenyl)methyl]malononitrile, approximately five times greater than that of the unsupported HPW, and exhibited a broad substrate scope for aromatic aldehydes.
Original languageEnglish
Article number409
JournalCatalysts
Volume9
Issue number5
DOIs
Publication statusPublished - 30 Apr 2019

Bibliographical note

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Keywords

  • 3-substituted indole
  • Condensation
  • H PW O
  • SBA-15

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