Hand somatosensory sub-cortical sources arehypoactive in migraine interictally: a functionalsource separation analysis

G. Coppola, C. Porcaro, F. Pierelli, S. Seri, F. Tecchio, G. di Lorenzo

Research output: Contribution to journalMeeting abstract

Abstract

Background: Recent morpho-functional evidences pointed out that abnormalities in the thalamus could play a major role in the expression of migraine neurophysiological and clinical correlates. Whether this phenomenon is primary or secondary to its functional disconnection from the brain stem remains to be determined.Aim: We used a Functional Source Separation algorithmof EEG signal to extract the activity of the different neuronal pools recruited at different latencies along the somatosensory pathway in interictal migraine without aura(MO) patients.
Method: Twenty MO patients and 20 healthy volunteers(HV) underwent EEG recording. Four ad-hoc functional constraints, two sub-cortical (FS14 at brain stem andFS16 at thalamic level) and two cortical (FS20 radial andFS22 tangential parietal sources), were used to extract the activity of successive stages of somatosensory information processing in response to the separate left and right median nerve electric stimulation. A band-pass digital filter (450–750 Hz) was applied offline in order to extract high-frequency oscillatory (HFO) activity from the broadband EEG signal.
Results: In both stimulated sides, significant reduced subcortical brain stem (FS14) and thalamic (FS16) HFO activations characterized MO patients when compared with HV. No difference emerged in the two cortical HFO activations between two groups.
Conclusion: Present results are the first neurophysiological evidence supporting the hypothesis that a functional disconnection of the thalamus from the subcortical monoaminergicsystem may underline the interictal cortical abnormal information processing in migraine. Further studiesare needed to investigate the precise directional connectivity across the entire primary subcortical and cortical somatosensory pathway in interictal MO.
Original languageEnglish
Article numberP0418
Pages (from-to)218-219
Number of pages2
JournalCephalalgia
Volume35
Issue number6 Suppl.
DOIs
Publication statusPublished - 31 May 2015
Event17th Congress of the International Headache Society - Valencia, Spain
Duration: 14 May 201517 May 2015

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Migraine Disorders
Brain Stem
Electroencephalography
Hand
Thalamus
Automatic Data Processing
Healthy Volunteers
Migraine without Aura
Median Nerve
Electric Stimulation

Bibliographical note

International Headache Society 2015 abstracts: 17th Congress of the International Headache Society, 14/05/15 → 17/05/15, Valencia, Spain.

Cite this

Coppola, G. ; Porcaro, C. ; Pierelli, F. ; Seri, S. ; Tecchio, F. ; di Lorenzo, G. / Hand somatosensory sub-cortical sources arehypoactive in migraine interictally: a functionalsource separation analysis. In: Cephalalgia. 2015 ; Vol. 35, No. 6 Suppl. pp. 218-219.
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abstract = "Background: Recent morpho-functional evidences pointed out that abnormalities in the thalamus could play a major role in the expression of migraine neurophysiological and clinical correlates. Whether this phenomenon is primary or secondary to its functional disconnection from the brain stem remains to be determined.Aim: We used a Functional Source Separation algorithmof EEG signal to extract the activity of the different neuronal pools recruited at different latencies along the somatosensory pathway in interictal migraine without aura(MO) patients. Method: Twenty MO patients and 20 healthy volunteers(HV) underwent EEG recording. Four ad-hoc functional constraints, two sub-cortical (FS14 at brain stem andFS16 at thalamic level) and two cortical (FS20 radial andFS22 tangential parietal sources), were used to extract the activity of successive stages of somatosensory information processing in response to the separate left and right median nerve electric stimulation. A band-pass digital filter (450–750 Hz) was applied offline in order to extract high-frequency oscillatory (HFO) activity from the broadband EEG signal. Results: In both stimulated sides, significant reduced subcortical brain stem (FS14) and thalamic (FS16) HFO activations characterized MO patients when compared with HV. No difference emerged in the two cortical HFO activations between two groups. Conclusion: Present results are the first neurophysiological evidence supporting the hypothesis that a functional disconnection of the thalamus from the subcortical monoaminergicsystem may underline the interictal cortical abnormal information processing in migraine. Further studiesare needed to investigate the precise directional connectivity across the entire primary subcortical and cortical somatosensory pathway in interictal MO.",
author = "G. Coppola and C. Porcaro and F. Pierelli and S. Seri and F. Tecchio and {di Lorenzo}, G.",
note = "International Headache Society 2015 abstracts: 17th Congress of the International Headache Society, 14/05/15 → 17/05/15, Valencia, Spain.",
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Coppola, G, Porcaro, C, Pierelli, F, Seri, S, Tecchio, F & di Lorenzo, G 2015, 'Hand somatosensory sub-cortical sources arehypoactive in migraine interictally: a functionalsource separation analysis', Cephalalgia, vol. 35, no. 6 Suppl., P0418, pp. 218-219. https://doi.org/10.1177/0333102415581304

Hand somatosensory sub-cortical sources arehypoactive in migraine interictally: a functionalsource separation analysis. / Coppola, G.; Porcaro, C.; Pierelli, F.; Seri, S.; Tecchio, F.; di Lorenzo, G.

In: Cephalalgia, Vol. 35, No. 6 Suppl., P0418, 31.05.2015, p. 218-219.

Research output: Contribution to journalMeeting abstract

TY - JOUR

T1 - Hand somatosensory sub-cortical sources arehypoactive in migraine interictally: a functionalsource separation analysis

AU - Coppola, G.

AU - Porcaro, C.

AU - Pierelli, F.

AU - Seri, S.

AU - Tecchio, F.

AU - di Lorenzo, G.

N1 - International Headache Society 2015 abstracts: 17th Congress of the International Headache Society, 14/05/15 → 17/05/15, Valencia, Spain.

PY - 2015/5/31

Y1 - 2015/5/31

N2 - Background: Recent morpho-functional evidences pointed out that abnormalities in the thalamus could play a major role in the expression of migraine neurophysiological and clinical correlates. Whether this phenomenon is primary or secondary to its functional disconnection from the brain stem remains to be determined.Aim: We used a Functional Source Separation algorithmof EEG signal to extract the activity of the different neuronal pools recruited at different latencies along the somatosensory pathway in interictal migraine without aura(MO) patients. Method: Twenty MO patients and 20 healthy volunteers(HV) underwent EEG recording. Four ad-hoc functional constraints, two sub-cortical (FS14 at brain stem andFS16 at thalamic level) and two cortical (FS20 radial andFS22 tangential parietal sources), were used to extract the activity of successive stages of somatosensory information processing in response to the separate left and right median nerve electric stimulation. A band-pass digital filter (450–750 Hz) was applied offline in order to extract high-frequency oscillatory (HFO) activity from the broadband EEG signal. Results: In both stimulated sides, significant reduced subcortical brain stem (FS14) and thalamic (FS16) HFO activations characterized MO patients when compared with HV. No difference emerged in the two cortical HFO activations between two groups. Conclusion: Present results are the first neurophysiological evidence supporting the hypothesis that a functional disconnection of the thalamus from the subcortical monoaminergicsystem may underline the interictal cortical abnormal information processing in migraine. Further studiesare needed to investigate the precise directional connectivity across the entire primary subcortical and cortical somatosensory pathway in interictal MO.

AB - Background: Recent morpho-functional evidences pointed out that abnormalities in the thalamus could play a major role in the expression of migraine neurophysiological and clinical correlates. Whether this phenomenon is primary or secondary to its functional disconnection from the brain stem remains to be determined.Aim: We used a Functional Source Separation algorithmof EEG signal to extract the activity of the different neuronal pools recruited at different latencies along the somatosensory pathway in interictal migraine without aura(MO) patients. Method: Twenty MO patients and 20 healthy volunteers(HV) underwent EEG recording. Four ad-hoc functional constraints, two sub-cortical (FS14 at brain stem andFS16 at thalamic level) and two cortical (FS20 radial andFS22 tangential parietal sources), were used to extract the activity of successive stages of somatosensory information processing in response to the separate left and right median nerve electric stimulation. A band-pass digital filter (450–750 Hz) was applied offline in order to extract high-frequency oscillatory (HFO) activity from the broadband EEG signal. Results: In both stimulated sides, significant reduced subcortical brain stem (FS14) and thalamic (FS16) HFO activations characterized MO patients when compared with HV. No difference emerged in the two cortical HFO activations between two groups. Conclusion: Present results are the first neurophysiological evidence supporting the hypothesis that a functional disconnection of the thalamus from the subcortical monoaminergicsystem may underline the interictal cortical abnormal information processing in migraine. Further studiesare needed to investigate the precise directional connectivity across the entire primary subcortical and cortical somatosensory pathway in interictal MO.

U2 - 10.1177/0333102415581304

DO - 10.1177/0333102415581304

M3 - Meeting abstract

VL - 35

SP - 218

EP - 219

JO - Cephalalgia

JF - Cephalalgia

SN - 0333-1024

IS - 6 Suppl.

M1 - P0418

ER -