TY - JOUR
T1 - HER-2/Epstein-Barr virus crosstalk in human gastric carcinogenesis: A novel concept of oncogene/oncovirus interaction
AU - Cyprian, Farhan S.
AU - Al-Antary , Noor
AU - Al Moustafa, Ala-Eddin
PY - 2017/6/29
Y1 - 2017/6/29
N2 - Gastric cancer is the fourth most common cancer and the second leading cause of cancer deaths worldwide. Additionally, it is well-known that metastatic cancer disease is a major cause of morbidity and mortality in cancer patients. Several investigations reported that HER-2 (ErbB-2 receptor) and Epstein-Barr virus (EBV) are important etiological factors in human gastric cancer, where either oncogene/oncovirus alone can derive a major event of cancer progression and metastasis via epithelial–mesenchymal transition (EMT). Herein, we discuss, for the first time, the possibility of HER-2/EBV-oncoproteins interaction in human gastric cancer initiation and/or progression.
AB - Gastric cancer is the fourth most common cancer and the second leading cause of cancer deaths worldwide. Additionally, it is well-known that metastatic cancer disease is a major cause of morbidity and mortality in cancer patients. Several investigations reported that HER-2 (ErbB-2 receptor) and Epstein-Barr virus (EBV) are important etiological factors in human gastric cancer, where either oncogene/oncovirus alone can derive a major event of cancer progression and metastasis via epithelial–mesenchymal transition (EMT). Herein, we discuss, for the first time, the possibility of HER-2/EBV-oncoproteins interaction in human gastric cancer initiation and/or progression.
UR - https://www.tandfonline.com/doi/full/10.1080/19336918.2017.1330244
U2 - 10.1080/19336918.2017.1330244
DO - 10.1080/19336918.2017.1330244
M3 - Article
SN - 1933-6918
VL - 12
SP - 1
EP - 4
JO - Cell Adhesion and Migration
JF - Cell Adhesion and Migration
IS - 1
ER -