HLA-A3 supermotif defined by quantitative structure-activity relationship analysis

Pingping Guan, Irini A. Doytchinova, Darren R. Flower

Research output: Contribution to journalArticle

Abstract

Activation of a cytotoxic T cell requires specific binding of antigenic peptides to major histocompatibility complex (MHC) molecules. This paper reports a study of peptides binding to members of the HLA-A3 superfamily using a recently developed 2D-QSAR method, called the additive method. Four alleles with high phenotype frequency were included in the study: A*0301, A*1101, A*3101 and A*6801. The influence of each of the 20 amino acids at each position of the peptide on binding was studied. A refined A3 supertype motif was defined in the study.
Original languageEnglish
Pages (from-to)11-18
Number of pages8
JournalProtein Engineering, Design and Selection
Volume16
Issue number1
DOIs
Publication statusPublished - Jan 2003

Keywords

  • a3-supertype
  • additive method
  • pls

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