HLA-A3 supermotif defined by quantitative structure-activity relationship analysis

Pingping Guan; Irini A. Doytchinova; Darren R. Flower

doi:10.1093/proeng/gzg005

HLA-A3 supermotif defined by quantitative structure-activity relationship analysis

Pingping Guan, Irini A. Doytchinova, Darren R. Flower

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Abstract

Activation of a cytotoxic T cell requires specific binding of antigenic peptides to major histocompatibility complex (MHC) molecules. This paper reports a study of peptides binding to members of the HLA-A3 superfamily using a recently developed 2D-QSAR method, called the additive method. Four alleles with high phenotype frequency were included in the study: A*0301, A*1101, A*3101 and A*6801. The influence of each of the 20 amino acids at each position of the peptide on binding was studied. A refined A3 supertype motif was defined in the study.

Original language	English
Pages (from-to)	11-18
Number of pages	8
Journal	Protein Engineering, Design and Selection
Volume	16
Issue number	1
DOIs	https://doi.org/10.1093/proeng/gzg005
Publication status	Published - Jan 2003

Keywords

a3-supertype
additive method
pls

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AB - Activation of a cytotoxic T cell requires specific binding of antigenic peptides to major histocompatibility complex (MHC) molecules. This paper reports a study of peptides binding to members of the HLA-A3 superfamily using a recently developed 2D-QSAR method, called the additive method. Four alleles with high phenotype frequency were included in the study: A*0301, A*1101, A*3101 and A*6801. The influence of each of the 20 amino acids at each position of the peptide on binding was studied. A refined A3 supertype motif was defined in the study.

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KW - pls

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HLA-A3 supermotif defined by quantitative structure-activity relationship analysis

Abstract

Keywords

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