TY - JOUR
T1 - Homology modeling of GPCRs.
AU - Simms, John
AU - Hall, Nathan E.
AU - Lam, Polo H.C.
AU - Miller, Laurence J.
AU - Christopoulos, Arthur
AU - Abagyan, Ruben
AU - Sexton, Patrick M.
PY - 2009/1/1
Y1 - 2009/1/1
N2 - Over 1,000 sequences likely to encode G protein-coupled receptors (GPCRs) are currently available in publicly accessible and proprietary databases and this number may grow with the refinement of a number of different genomes. However, despite recent efforts in the crystallization of these proteins, homology modeling approaches are becoming widely used as a method for obtaining quantitative and qualitative information for structure-based drug design as well as the interpretation of experimental data.
AB - Over 1,000 sequences likely to encode G protein-coupled receptors (GPCRs) are currently available in publicly accessible and proprietary databases and this number may grow with the refinement of a number of different genomes. However, despite recent efforts in the crystallization of these proteins, homology modeling approaches are becoming widely used as a method for obtaining quantitative and qualitative information for structure-based drug design as well as the interpretation of experimental data.
UR - http://www.scopus.com/inward/record.url?scp=67650351973&partnerID=8YFLogxK
UR - https://link.springer.com/protocol/10.1007%2F978-1-60327-317-6_7
U2 - 10.1007/978-1-60327-317-6_7
DO - 10.1007/978-1-60327-317-6_7
M3 - Article
C2 - 19513644
AN - SCOPUS:67650351973
SN - 1064-3745
VL - 552
SP - 97
EP - 113
JO - Methods in molecular biology (Clifton, N.J.)
JF - Methods in molecular biology (Clifton, N.J.)
ER -