Homology Modelling of G Protein-Coupled Receptors

John Simms*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter contains sections titled:

Introduction

Methods and approaches

Troubleshooting

Automated methods for generating models of GPCRs

References
Original languageEnglish
Title of host publicationG Protein-Coupled Receptors
Subtitle of host publicationEssential Methods
PublisherWiley-Blackwell
Chapter13
Pages251-273
Number of pages23
ISBN (Print)9780470749142
DOIs
Publication statusPublished - 25 Jan 2010

Fingerprint

G-Protein-Coupled Receptors

Keywords

  • Automated methods for models of GPCRs generation
  • Executing MODELLER input in generating homology models
  • Functional characterization of protein sequence and three-dimensional (3D) structure of protein
  • Homology modelling of G protein-coupled receptors
  • Homology modelling protocol and selection structural template from Protein Data Bank (PDB)
  • MODELLER, installed on local or networked computer
  • Protocol 13.4 modelling loops in GPCRs
  • ROBETTA server - automated front end to successful ROSETTA method
  • Sequence for query structure - referred to as 'target'
  • Variable 'sequence' in MODELLER Python script

Cite this

Simms, J. (2010). Homology Modelling of G Protein-Coupled Receptors. In G Protein-Coupled Receptors: Essential Methods (pp. 251-273). Wiley-Blackwell. https://doi.org/10.1002/9780470749210.ch13
Simms, John. / Homology Modelling of G Protein-Coupled Receptors. G Protein-Coupled Receptors: Essential Methods. Wiley-Blackwell, 2010. pp. 251-273
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Simms, J 2010, Homology Modelling of G Protein-Coupled Receptors. in G Protein-Coupled Receptors: Essential Methods. Wiley-Blackwell, pp. 251-273. https://doi.org/10.1002/9780470749210.ch13

Homology Modelling of G Protein-Coupled Receptors. / Simms, John.

G Protein-Coupled Receptors: Essential Methods. Wiley-Blackwell, 2010. p. 251-273.

Research output: Chapter in Book/Report/Conference proceedingChapter

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KW - Protocol 13.4 modelling loops in GPCRs

KW - ROBETTA server - automated front end to successful ROSETTA method

KW - Sequence for query structure - referred to as 'target'

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Simms J. Homology Modelling of G Protein-Coupled Receptors. In G Protein-Coupled Receptors: Essential Methods. Wiley-Blackwell. 2010. p. 251-273 https://doi.org/10.1002/9780470749210.ch13