Homology Modelling of G Protein-Coupled Receptors

John Simms*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter contains sections titled:

Introduction

Methods and approaches

Troubleshooting

Automated methods for generating models of GPCRs

References
Original languageEnglish
Title of host publicationG Protein-Coupled Receptors
Subtitle of host publicationEssential Methods
PublisherWiley-Blackwell
Chapter13
Pages251-273
Number of pages23
ISBN (Print)9780470749142
DOIs
Publication statusPublished - 25 Jan 2010

Keywords

  • Automated methods for models of GPCRs generation
  • Executing MODELLER input in generating homology models
  • Functional characterization of protein sequence and three-dimensional (3D) structure of protein
  • Homology modelling of G protein-coupled receptors
  • Homology modelling protocol and selection structural template from Protein Data Bank (PDB)
  • MODELLER, installed on local or networked computer
  • Protocol 13.4 modelling loops in GPCRs
  • ROBETTA server - automated front end to successful ROSETTA method
  • Sequence for query structure - referred to as 'target'
  • Variable 'sequence' in MODELLER Python script

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