H5PW10V2O40@VOx/SBA-15-NH2 catalyst for the solventless synthesis of 3-substituted indoles

Narges Mahdizadeh Ghohe, Reza Tayebee*, Mostafa M. Amini, Amin Osatiashtiani, Mark A. Isaacs, Adam F. Lee

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Functionalization of mesoporous SBA-15 frameworks by transition metal oxides offers a flexible route to fabricate new heterogeneous catalysts. Here, an inorganic-organic hybrid nanoporous catalyst H5PW10V2O40@VOx/SBA-15-NH2, was prepared and utilized as an efficient, eco-friendly, and recyclable catalyst for the one-pot, multi-component synthesis of 3-substituted indoles by indole substitution with aldehydes and malononitrile under solvent-free conditions. Catalysts were prepared by the non-covalent attachment of H5PW10V2O40 to a 3 wt%VOx/SBA-15 nanoporous support through a 3-(triethoxysilyl)propylamine linker. VOx/SBA-15 was prepared by a one-pot hydrothermal synthesis from TEOS and vanadium(V) oxytri-tert-butoxide [VO(O-tBu)3]. The resulting H5PW10V2O40@VOx/SBA-15-NH2 material was characterized by bulk and surface analysis including N2 porosimetry, FE-SEM, XRD, XPS, FT-IR, TGA-DTA, UV–Vis and ICP-OES, evidencing retention of the heteropolyacid Keggin structure. H5PW10V2O40@VOx/SBA-15-NH2 exhibits high activity and excellent yields (70–95%) of 3-substituted indoles under mild conditions, with negligible deactivation.
Original languageEnglish
Pages (from-to)5862-5871
Issue number40
Early online date18 Aug 2017
Publication statusPublished - 5 Oct 2017

Bibliographical note

© 2017, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/


  • vanadia
  • SBA-15
  • heteropolyacid
  • 3-substituted indoles
  • solventless


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