Human drug metabolism: an introduction

Research output: Book/ReportBook

Abstract

Human Drug Metabolism, An Introduction, Second Edition provides an accessible introduction to the subject and will be particularly invaluable to those who already have some understanding of the life sciences. Completely revised and updated throughout, the new edition focuses only on essential chemical detail and includes patient case histories to illustrate the clinical consequences of changes in drug metabolism and its impact on patient welfare. After underlining the relationship between efficacy, toxicity and drug concentration, the book then considers how metabolizing systems operate and how they impact upon drug concentration, both under drug pressure and during inhibition. Factors affecting drug metabolism, such as genetic polymorphisms, age and diet are discussed and how metabolism can lead to toxicity is explained. The book concludes with the role of drug metabolism in the commercial development of therapeutic agents as well as the pharmacology of some illicit drugs.

LanguageEnglish
Place of PublicationOxford (UK)
PublisherWiley-Blackwell
Number of pages346
Edition2nd
ISBN (Electronic)978-0-470-68933-2
ISBN (Print)978-0-470-74217-4, 978-0-470-74216-7
DOIs
Publication statusPublished - 12 Apr 2010

Fingerprint

Metabolism
Pharmaceutical Preparations
Toxicity
Biological Science Disciplines
Enzyme inhibition
Street Drugs
Genetic Polymorphisms
Drug-Related Side Effects and Adverse Reactions
Nutrition
Polymorphism
Pharmacology
Diet
Pressure

Cite this

Coleman, Michael D. / Human drug metabolism : an introduction. 2nd ed. Oxford (UK) : Wiley-Blackwell, 2010. 346 p.
@book{00b913de67a34b779be3267d1191db77,
title = "Human drug metabolism: an introduction",
abstract = "Human Drug Metabolism, An Introduction, Second Edition provides an accessible introduction to the subject and will be particularly invaluable to those who already have some understanding of the life sciences. Completely revised and updated throughout, the new edition focuses only on essential chemical detail and includes patient case histories to illustrate the clinical consequences of changes in drug metabolism and its impact on patient welfare. After underlining the relationship between efficacy, toxicity and drug concentration, the book then considers how metabolizing systems operate and how they impact upon drug concentration, both under drug pressure and during inhibition. Factors affecting drug metabolism, such as genetic polymorphisms, age and diet are discussed and how metabolism can lead to toxicity is explained. The book concludes with the role of drug metabolism in the commercial development of therapeutic agents as well as the pharmacology of some illicit drugs.",
author = "Coleman, {Michael D.}",
year = "2010",
month = "4",
day = "12",
doi = "10.1002/9780470689332",
language = "English",
isbn = "978-0-470-74217-4",
publisher = "Wiley-Blackwell",
address = "United States",
edition = "2nd",

}

Human drug metabolism : an introduction. / Coleman, Michael D.

2nd ed. Oxford (UK) : Wiley-Blackwell, 2010. 346 p.

Research output: Book/ReportBook

TY - BOOK

T1 - Human drug metabolism

T2 - an introduction

AU - Coleman, Michael D.

PY - 2010/4/12

Y1 - 2010/4/12

N2 - Human Drug Metabolism, An Introduction, Second Edition provides an accessible introduction to the subject and will be particularly invaluable to those who already have some understanding of the life sciences. Completely revised and updated throughout, the new edition focuses only on essential chemical detail and includes patient case histories to illustrate the clinical consequences of changes in drug metabolism and its impact on patient welfare. After underlining the relationship between efficacy, toxicity and drug concentration, the book then considers how metabolizing systems operate and how they impact upon drug concentration, both under drug pressure and during inhibition. Factors affecting drug metabolism, such as genetic polymorphisms, age and diet are discussed and how metabolism can lead to toxicity is explained. The book concludes with the role of drug metabolism in the commercial development of therapeutic agents as well as the pharmacology of some illicit drugs.

AB - Human Drug Metabolism, An Introduction, Second Edition provides an accessible introduction to the subject and will be particularly invaluable to those who already have some understanding of the life sciences. Completely revised and updated throughout, the new edition focuses only on essential chemical detail and includes patient case histories to illustrate the clinical consequences of changes in drug metabolism and its impact on patient welfare. After underlining the relationship between efficacy, toxicity and drug concentration, the book then considers how metabolizing systems operate and how they impact upon drug concentration, both under drug pressure and during inhibition. Factors affecting drug metabolism, such as genetic polymorphisms, age and diet are discussed and how metabolism can lead to toxicity is explained. The book concludes with the role of drug metabolism in the commercial development of therapeutic agents as well as the pharmacology of some illicit drugs.

UR - http://www.scopus.com/inward/record.url?scp=84982224067&partnerID=8YFLogxK

UR - http://onlinelibrary.wiley.com/book/10.1002/9780470689332

U2 - 10.1002/9780470689332

DO - 10.1002/9780470689332

M3 - Book

SN - 978-0-470-74217-4

SN - 978-0-470-74216-7

BT - Human drug metabolism

PB - Wiley-Blackwell

CY - Oxford (UK)

ER -