Hyperlocomotion test for assessing behavioral disorders

Dan Ma, Paul C. Guest*

*Corresponding author for this work

Research output: Chapter in Book/Published conference outputChapter

Abstract

Under- or overfeeding during pregnancy can lead to behavioral deficits in the offspring in later life. Here, we present a protocol for setting up and carrying out the hyperlocomotion test for assessing behavioral symptoms such as psychosis or mania. As an example, we use the acute rat phencyclidine-injection model which exhibits hyperlocomotion and stereotypic behaviors, resembling the positive symptoms of schizophrenia.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
EditorsP. Guest
PublisherHumana Press
Pages421-425
Number of pages5
ISBN (Electronic)978-1-4939-7614-0
ISBN (Print)978-1-4939-7613-3
DOIs
Publication statusPublished - 30 Jan 2018

Publication series

NameMethods in Molecular Biology
Volume1735
ISSN (Print)1064-3745

Keywords

  • Behavioral deficits
  • Hyperlocomotion test
  • Nutritional programming
  • PCP
  • Psychosis

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