Simple stirring of a mixture of the alkynyl(phenyl)iodonium salts 1 with 2-aminopyrimidine 2 in chloroform under reflux for two hours in the presence of K2CO3 gave, after workup, the 2-substituted imidazo[1,2-]pyrimidines 3 in moderate to good yields. A possible mechanism for the formation of 3 involves the intramolecular cyclization of the intermediate alkylidenecarbene 6.
- alkynyl(phenyl)iodonium salts 1
- 2-aminopyrimidine 2 in chloroform
- 2-substituted imidazo[1
- 2-]pyrimidines 3
- intramolecular cyclization
- intermediate alkylidenecarbene 6