TY - JOUR
T1 - Hypervalent iodine in synthesis 93. A facile synthesis of 2-substituted imidazo[1,2-a]pyrimidines by cyclocondensation of alkynyl(phenyl)iodonium salts and 2-aminopyrimidine
AU - Zhi, Liu
AU - Chen, Zhen-Chu
AU - Zheng, Qinguo
PY - 2003/9
Y1 - 2003/9
N2 - Simple stirring of a mixture of the alkynyl(phenyl)iodonium salts 1 with 2-aminopyrimidine 2 in chloroform under reflux for two hours in the presence of K2CO3 gave, after workup, the 2-substituted imidazo[1,2-]pyrimidines 3 in moderate to good yields. A possible mechanism for the formation of 3 involves the intramolecular cyclization of the intermediate alkylidenecarbene 6.
AB - Simple stirring of a mixture of the alkynyl(phenyl)iodonium salts 1 with 2-aminopyrimidine 2 in chloroform under reflux for two hours in the presence of K2CO3 gave, after workup, the 2-substituted imidazo[1,2-]pyrimidines 3 in moderate to good yields. A possible mechanism for the formation of 3 involves the intramolecular cyclization of the intermediate alkylidenecarbene 6.
KW - alkynyl(phenyl)iodonium salts 1
KW - 2-aminopyrimidine 2 in chloroform
KW - reflux
KW - K2CO3
KW - 2-substituted imidazo[1
KW - 2-]pyrimidines 3
KW - intramolecular cyclization
KW - intermediate alkylidenecarbene 6
UR - http://www.scopus.com/inward/record.url?scp=0242361693&partnerID=8YFLogxK
UR - http://onlinelibrary.wiley.com/doi/10.1002/jhet.5570400526/abstract
U2 - 10.1002/jhet.5570400526
DO - 10.1002/jhet.5570400526
M3 - Article
SN - 0022-152X
VL - 40
SP - 909
EP - 911
JO - Journal of Heterocyclic Chemistry
JF - Journal of Heterocyclic Chemistry
IS - 5
ER -