Imaging of early stage breast cancer with circularly polarized light

Viktor Dremin; Dmytro Anin; Oleksii Sieryi; Mariia Borovkova; Juha Näpänkangas; Igor Meglinski; Alexander Bykov

doi:10.1117/12.2554166

Imaging of early stage breast cancer with circularly polarized light

Viktor Dremin^*
, Dmytro Anin
, Oleksii Sieryi
, Mariia Borovkova
, Juha Näpänkangas
, Igor Meglinski
, Alexander Bykov

^*Corresponding author for this work

Faculty of Information Technology and Electrical Engineering
Oulu University Hospital

Research output: Contribution to journal › Conference article › peer-review

29 Citations (SciVal)

29 Downloads (Pure)

Abstract

In this study, we utilize the properties of polarized light for the analysis of paraffin-embedded breast cancer samples. We perform the measurements of the full Stokes vector of back-reflected radiation and calculate the degree of polarization as a diagnostic criterion for the separation of healthy and cancer sample sections. We show that circularly polarized light scattered within the breast sample is sensitive to the presence of cancer cells. The degree of the polarization of the reected light was found to be the most sensitive parameter for the reliable differentiation of tissue.

Original language	English
Article number	1136304
Journal	Proceedings of SPIE - The International Society for Optical Engineering
Volume	11363
DOIs	https://doi.org/10.1117/12.2554166
Publication status	Published - 7 Apr 2020
Event	Tissue Optics and Photonics 2020 - None, France Duration: 6 Apr 2020 → 10 Apr 2020

Bibliographical note

Copyright 2020 SPIE. One print or electronic copy may be made for personal use only. Systematic reproduction, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.

Funding

Authors acknowledge the support of the Academy of Finland (grants: 314369 and 325097), the ATTRACT project funded by the EU under Grant Agreement 777222. This study was also supported by the Russian Science Foundation under projects No. 19-79-00082 (experimental data collection). Authors acknowledge Northern Finland Biobank Borealis, Oulu, Finland (www.ppshp.fi/biopankki) for providing the breast cancer samples.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Breast cancer
Degree of polarization
Polarimetric imaging
Stokes polarimetry

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10.1117/12.2554166

Imaging of early stage breast cancer with circularly polarized light
Copyright 2020 SPIE. One print or electronic copy may be made for personal use only. Systematic reproduction, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.
Final published version, 703 KB

Cite this

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abstract = "In this study, we utilize the properties of polarized light for the analysis of paraffin-embedded breast cancer samples. We perform the measurements of the full Stokes vector of back-reflected radiation and calculate the degree of polarization as a diagnostic criterion for the separation of healthy and cancer sample sections. We show that circularly polarized light scattered within the breast sample is sensitive to the presence of cancer cells. The degree of the polarization of the reected light was found to be the most sensitive parameter for the reliable differentiation of tissue.",

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note = "Copyright 2020 SPIE. One print or electronic copy may be made for personal use only. Systematic reproduction, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited. ; Tissue Optics and Photonics 2020 ; Conference date: 06-04-2020 Through 10-04-2020",

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T1 - Imaging of early stage breast cancer with circularly polarized light

AU - Dremin, Viktor

AU - Anin, Dmytro

AU - Sieryi, Oleksii

AU - Borovkova, Mariia

AU - Näpänkangas, Juha

AU - Meglinski, Igor

AU - Bykov, Alexander

N1 - Copyright 2020 SPIE. One print or electronic copy may be made for personal use only. Systematic reproduction, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.

PY - 2020/4/7

Y1 - 2020/4/7

N2 - In this study, we utilize the properties of polarized light for the analysis of paraffin-embedded breast cancer samples. We perform the measurements of the full Stokes vector of back-reflected radiation and calculate the degree of polarization as a diagnostic criterion for the separation of healthy and cancer sample sections. We show that circularly polarized light scattered within the breast sample is sensitive to the presence of cancer cells. The degree of the polarization of the reected light was found to be the most sensitive parameter for the reliable differentiation of tissue.

AB - In this study, we utilize the properties of polarized light for the analysis of paraffin-embedded breast cancer samples. We perform the measurements of the full Stokes vector of back-reflected radiation and calculate the degree of polarization as a diagnostic criterion for the separation of healthy and cancer sample sections. We show that circularly polarized light scattered within the breast sample is sensitive to the presence of cancer cells. The degree of the polarization of the reected light was found to be the most sensitive parameter for the reliable differentiation of tissue.

KW - Breast cancer

KW - Degree of polarization

KW - Polarimetric imaging

KW - Stokes polarimetry

UR - https://www.scopus.com/pages/publications/85085566342

UR - https://www.spiedigitallibrary.org/conference-proceedings-of-spie/11363/2554166/Imaging-of-early-stage-breast-cancer-with-circularly-polarized-light/10.1117/12.2554166.full

U2 - 10.1117/12.2554166

DO - 10.1117/12.2554166

M3 - Conference article

AN - SCOPUS:85085566342

SN - 0277-786X

VL - 11363

JO - Proceedings of SPIE - The International Society for Optical Engineering

JF - Proceedings of SPIE - The International Society for Optical Engineering

M1 - 1136304

T2 - Tissue Optics and Photonics 2020

Y2 - 6 April 2020 through 10 April 2020

ER -

Imaging of early stage breast cancer with circularly polarized light

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

Access to Document

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