Impairment of calcium ATPases by high glucose and potential pharmacological protection

L. Horáková, M.K. Strosova, C.M. Spickett, D. Blaskovic

Research output: Contribution to journalArticle

Abstract

The review deals with impairment of Ca2+-ATPases by high glucose or its derivatives in vitro, as well as in human diabetes and experimental animal models. Acute increases in glucose level strongly correlate with oxidative stress. Dysfunction of Ca2+-ATPases in diabetic and in some cases even in nondiabetic conditions may result in nitration of and in irreversible modification of cysteine-674. Nonenyzmatic protein glycation might lead to alteration of Ca2+-ATPase structure and function contributing to Ca2+ imbalance and thus may be involved in development of chronic complications of diabetes. The susceptibility to glycation is probably due to the relatively high percentage of lysine and arginine residues at the ATP binding and phosphorylation domains. Reversible glycation may develop into irreversible modifications (advanced glycation end products, AGEs). Sites of SERCA AGEs are depicted in this review. Finally, several mechanisms of prevention of Ca2+-pump glycation, and their advantages and disadvantages are discussed. © 2013 Informa UK, Ltd.

LanguageEnglish
Pages81-92
Number of pages12
JournalFree Radical Research
Volume47
Issue numberS1
DOIs
Publication statusPublished - Aug 2013

Fingerprint

Calcium-Transporting ATPases
Pharmacology
Medical problems
Glucose
Nitration
Advanced Glycosylation End Products
Phosphorylation
Oxidative stress
Diabetes Complications
Lysine
Cysteine
Arginine
Animals
Oxidative Stress
Animal Models
Adenosine Triphosphate
Pumps
Derivatives
Proteins

Keywords

  • cysteine-674
  • diabetes
  • glycation
  • ntrotyrosine
  • pathway
  • polyol

Cite this

Horáková, L. ; Strosova, M.K. ; Spickett, C.M. ; Blaskovic, D. / Impairment of calcium ATPases by high glucose and potential pharmacological protection. In: Free Radical Research. 2013 ; Vol. 47, No. S1. pp. 81-92.
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Impairment of calcium ATPases by high glucose and potential pharmacological protection. / Horáková, L.; Strosova, M.K.; Spickett, C.M.; Blaskovic, D.

In: Free Radical Research, Vol. 47, No. S1, 08.2013, p. 81-92.

Research output: Contribution to journalArticle

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