Improved General and Oral Health in Diabetic Patients by an Okinawan-Based Nordic Diet: A Pilot Study

Helene Holmer, Cecilia Widén, Viveca Wallin Bengtsson, Michael Coleman, Björn Wohlfart, Stig Steen, Rutger Persson, Klas Sjöberg

Research output: Contribution to journalArticle

Abstract

Periodontal disease, periodontitis as well as the preceding gingivitis, has been associated with both obesity and diabetes. Studies have shown that diet changes can lead to a lower incidence of such inflammation. The aim of the present case series over four weeks was to study the effects on medical and dental conditions in patients with type 2 diabetes of the consumption of the Okinawan-based Nordic Diet (OBND®). Medical and dental examinations were performed to estimate the general health and gingivitis/periodontitis. Serum cytokine levels were assessed using Luminex technology. Eight of ten study participants completed the study. All participants lost weight (p = 0.012). Six out of seven that were treated with insulin could reduce their insulin intake after two weeks with OBND®. The reduction was about 16 units which corresponds to a 34% relative reduction compared to the starting point (range 15–63%). Fasting blood glucose values fell (p = 0.035). Hemoglobin A1c (HbA1c) (p = 0.01), triglycerides (p = 0.05), and low-density lipoprotein (LDL) (p = 0.05) were also reduced. Bleeding on probing changed from ~28% before any dietary changes to ~13% after two weeks with OBND® (p = 0.01). The reduction in gingival bleeding was as substantial as might be expected from one session of professional tooth cleaning. Markers of inflammation were also reduced. The OBND® thus showed significant promise in alleviating the impact of diabetes on dental as well as general health.
Original languageEnglish
Article number1949
JournalInternational Journal of Molecular Sciences
Volume19
Issue number7
DOIs
Publication statusPublished - 3 Jul 2018

Fingerprint

diets
Oral Health
Nutrition
health
Health
Diet
Tooth
Medical problems
bleeding
insulin
Gingivitis
Periodontitis
Insulin
fasting
obesity
Hemorrhage
Inflammation
lipoproteins
Lipoproteins
Hemoglobin

Bibliographical note

© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access
article distributed under the terms and conditions of the Creative Commons Attribution
(CC BY) license (http://creativecommons.org/licenses/by/4.0/).

Keywords

  • diet
  • oral health
  • metabolic disorder
  • cytokines
  • bleeding on probing
  • clinical study

Cite this

Holmer, Helene ; Widén, Cecilia ; Wallin Bengtsson, Viveca ; Coleman, Michael ; Wohlfart, Björn ; Steen, Stig ; Persson, Rutger ; Sjöberg, Klas. / Improved General and Oral Health in Diabetic Patients by an Okinawan-Based Nordic Diet : A Pilot Study. In: International Journal of Molecular Sciences. 2018 ; Vol. 19, No. 7.
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note = "{\circledC} 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).",
year = "2018",
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Improved General and Oral Health in Diabetic Patients by an Okinawan-Based Nordic Diet : A Pilot Study. / Holmer, Helene; Widén, Cecilia; Wallin Bengtsson, Viveca; Coleman, Michael; Wohlfart, Björn; Steen, Stig; Persson, Rutger; Sjöberg, Klas.

In: International Journal of Molecular Sciences, Vol. 19, No. 7, 1949, 03.07.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Improved General and Oral Health in Diabetic Patients by an Okinawan-Based Nordic Diet

T2 - A Pilot Study

AU - Holmer, Helene

AU - Widén, Cecilia

AU - Wallin Bengtsson, Viveca

AU - Coleman, Michael

AU - Wohlfart, Björn

AU - Steen, Stig

AU - Persson, Rutger

AU - Sjöberg, Klas

N1 - © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PY - 2018/7/3

Y1 - 2018/7/3

N2 - Periodontal disease, periodontitis as well as the preceding gingivitis, has been associated with both obesity and diabetes. Studies have shown that diet changes can lead to a lower incidence of such inflammation. The aim of the present case series over four weeks was to study the effects on medical and dental conditions in patients with type 2 diabetes of the consumption of the Okinawan-based Nordic Diet (OBND®). Medical and dental examinations were performed to estimate the general health and gingivitis/periodontitis. Serum cytokine levels were assessed using Luminex technology. Eight of ten study participants completed the study. All participants lost weight (p = 0.012). Six out of seven that were treated with insulin could reduce their insulin intake after two weeks with OBND®. The reduction was about 16 units which corresponds to a 34% relative reduction compared to the starting point (range 15–63%). Fasting blood glucose values fell (p = 0.035). Hemoglobin A1c (HbA1c) (p = 0.01), triglycerides (p = 0.05), and low-density lipoprotein (LDL) (p = 0.05) were also reduced. Bleeding on probing changed from ~28% before any dietary changes to ~13% after two weeks with OBND® (p = 0.01). The reduction in gingival bleeding was as substantial as might be expected from one session of professional tooth cleaning. Markers of inflammation were also reduced. The OBND® thus showed significant promise in alleviating the impact of diabetes on dental as well as general health.

AB - Periodontal disease, periodontitis as well as the preceding gingivitis, has been associated with both obesity and diabetes. Studies have shown that diet changes can lead to a lower incidence of such inflammation. The aim of the present case series over four weeks was to study the effects on medical and dental conditions in patients with type 2 diabetes of the consumption of the Okinawan-based Nordic Diet (OBND®). Medical and dental examinations were performed to estimate the general health and gingivitis/periodontitis. Serum cytokine levels were assessed using Luminex technology. Eight of ten study participants completed the study. All participants lost weight (p = 0.012). Six out of seven that were treated with insulin could reduce their insulin intake after two weeks with OBND®. The reduction was about 16 units which corresponds to a 34% relative reduction compared to the starting point (range 15–63%). Fasting blood glucose values fell (p = 0.035). Hemoglobin A1c (HbA1c) (p = 0.01), triglycerides (p = 0.05), and low-density lipoprotein (LDL) (p = 0.05) were also reduced. Bleeding on probing changed from ~28% before any dietary changes to ~13% after two weeks with OBND® (p = 0.01). The reduction in gingival bleeding was as substantial as might be expected from one session of professional tooth cleaning. Markers of inflammation were also reduced. The OBND® thus showed significant promise in alleviating the impact of diabetes on dental as well as general health.

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KW - metabolic disorder

KW - cytokines

KW - bleeding on probing

KW - clinical study

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U2 - 10.3390/ijms19071949

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