Improving brain drug targeting through exploitation of the nose-to-brain route: a physiological and pharmacokinetic perspective

R.K.S. Badhan, M. Kaur, S. Lungare, S. Obuobi

Research output: Contribution to journalArticle

Abstract

With an ageing population and increasing prevalence of central-nervous system (CNS) disorders new approaches are required to sustain the development and successful delivery of therapeutics into the brain and CNS. CNS drug delivery is challenging due to the impermeable nature of the brain microvascular endothelial cells that form the blood-brain barrier (BBB) and which prevent the entry of a wide range of therapeutics into the brain. This review examines the role intranasal delivery may play in achieving direct brain delivery, for small molecular weight drugs, macromolecular therapeutics and cell-based therapeutics, by exploitation of the olfactory and trigeminal nerve pathways. This approach is thought to deliver drugs into the brain and CNS through bypassing the BBB. Details of the mechanism of transfer of administrated therapeutics, the pathways that lead to brain deposition, with a specific focus on therapeutic pharmacokinetics, and examples of successful CNS delivery will be explored.

LanguageEnglish
Pages458-471
Number of pages14
JournalCurrent Drug Delivery
Volume11
Issue number4
DOIs
Publication statusPublished - 30 Jun 2014

Fingerprint

Drug Delivery Systems
Nose
Pharmacokinetics
Brain
Central Nervous System
Blood-Brain Barrier
Therapeutics
Central Nervous System Agents
Olfactory Nerve
Trigeminal Nerve
Central Nervous System Diseases
Pharmaceutical Preparations
Endothelial Cells
Molecular Weight
Population

Keywords

  • blood-brain barrier
  • brain
  • central nervous system
  • nasal
  • neuron
  • olfactory
  • pharmacokinetics
  • trigeminal

Cite this

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Improving brain drug targeting through exploitation of the nose-to-brain route : a physiological and pharmacokinetic perspective. / Badhan, R.K.S.; Kaur, M.; Lungare, S.; Obuobi, S.

In: Current Drug Delivery, Vol. 11, No. 4, 30.06.2014, p. 458-471.

Research output: Contribution to journalArticle

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