In silico identification of novel G protein coupled receptors

Matthew N. Davies; Darren R. Flower

doi:10.1007/978-1-60327-310-7_2

In silico identification of novel G protein coupled receptors

Matthew N. Davies, Darren R. Flower

Research output: Chapter in Book/Published conference output › Chapter (peer-reviewed) › peer-review

Abstract

G-protein coupled receptors (GPCRs) are a superfamily of membrane integral proteins responsible for a large number of physiological functions. Approximately 50% of marketed drugs are targeted toward a GPCR. Despite showing a high degree of structural homology, there is a large variance in sequence within the GPCR superfamily which has lead to difficulties in identifying and classifying potential new GPCR proteins. Here the various computational techniques that can be used to characterize a novel GPCR protein are discussed, including both alignment-based and alignment-free approaches. In addition, the application of homology modeling to building the three-dimensional structures of GPCRs is described.

Original language	English
Title of host publication	Membrane proteomics
Subtitle of host publication	methods and protocols
Editors	Matthew J. Peirce, Robin Wait
Publisher	Humana Press
Pages	25-36
Number of pages	12
ISBN (Electronic)	978-1-60327-310-7
ISBN (Print)	978-1-60327-309-1
DOIs	https://doi.org/10.1007/978-1-60327-310-7_2
Publication status	Published - 2009

Publication series

Name	Methods in molecular biology
Publisher	Springer
Volume	528
ISSN (Print)	1064-3745
ISSN (Electronic)	1940-6029

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10.1007/978-1-60327-310-7_2

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AB - G-protein coupled receptors (GPCRs) are a superfamily of membrane integral proteins responsible for a large number of physiological functions. Approximately 50% of marketed drugs are targeted toward a GPCR. Despite showing a high degree of structural homology, there is a large variance in sequence within the GPCR superfamily which has lead to difficulties in identifying and classifying potential new GPCR proteins. Here the various computational techniques that can be used to characterize a novel GPCR protein are discussed, including both alignment-based and alignment-free approaches. In addition, the application of homology modeling to building the three-dimensional structures of GPCRs is described.

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ER -

In silico identification of novel G protein coupled receptors

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