In silico prediction of peptide-MHC binding affinity using SVRMHC

Research output

Research output per year 2007 2007 2007

• 5 Chapter (peer-reviewed)
• 1 Edited Book
• 1 Foreword/postscript

Research output per year

Research output per year

Search results

• Chapter (peer-reviewed)

  Immunoinformatics and the in silico prediction of immunogenicity: an introduction

  Flower, D. R., 16 Jul 2007, Immunoinformatics: predicting immunogenicity in silico. Flower, D. R. (ed.). Totowa, NJ (US): Humana Press, p. 1-15 15 p. (Methods in molecular biology™; vol. 409).

  Research output: Chapter in Book/Published conference output › Chapter (peer-reviewed) › peer-review

  • Computer Simulation 100%
  • Immune System 84%
  • Informatics 67%
  • Subunit Vaccines 64%
  • Adaptive Immunity 53%

• Molecular dynamics simulations: bring biomolecular structures alive on a computer

  Wan, S., Coveney, P. V. & Flower, D. R., 16 Jul 2007, Immunoinformatics: predicting immunogenicity in silico. Flowers, D. R. (ed.). Totowa, NJ (US): Humana Press, p. 321-339 19 p. (Methods in molecular biology™; vol. 409).

  Research output: Chapter in Book/Published conference output › Chapter (peer-reviewed) › peer-review

  • Molecular Dynamics Simulation 100%
  • Drug Design 25%
  • Vaccines 16%

• Static energy analysis of MHC class I and class II peptide-binding affinity

  Davies, M. N. & Flower, D. R., 16 Jul 2007, Immunoinformatics: predicting immunogenicity in silico. Flowers, D. R. (ed.). Totowa, NJ (US): Humana Press, p. 309-320 12 p. (Methods in molecular biology™; vol. 409).

  Research output: Chapter in Book/Published conference output › Chapter (peer-reviewed)

  • Major Histocompatibility Complex 100%
  • Peptides 62%
  • T-Cell Antigen Receptor 33%
  • Vaccines 24%
  • Alleles 23%

• The classification of HLA supertypes by GRID/CPCA and hierarchical clustering methods

  Guan, P., Doytchinova, I. A. & Flower, D. R., 16 Jul 2007, Immunoioformatics: prediciting immunogenicity in silco. Flower, D. R. (ed.). Totowa, NJ (US): Humana Press, p. 143-154 12 p. (Methods in molecular biology™; vol. 409).

  Research output: Chapter in Book/Published conference output › Chapter (peer-reviewed) › peer-review

  • N-cyclopropyl adenosine-5'-carboxamide 100%
  • HLA Antigens 52%
  • Cluster Analysis 45%
  • Principal Component Analysis 27%
  • Least-Squares Analysis 9%

• Toward the prediction of class I and II mouse major histocompatibility complex-peptide-binding affinity: in silico bioinformatic step-by-step guide using quantitative structure-activity relationships

  Hattotuwagama, C. K., Doytchinova, I. A. & Flower, D. R., 16 Jul 2007, Immunoinformatics: predicting Immunogenicity in silico. Flowers, D. R. (ed.). Totowa, NJ (US): Humana Press, p. 227-245 19 p. (Methods in molecular biology™; vol. 409).

  Research output: Chapter in Book/Published conference output › Chapter (peer-reviewed) › peer-review

  • Quantitative Structure-Activity Relationship 100%
  • Major Histocompatibility Complex 74%
  • Computer Simulation 68%
  • Computational Biology 68%
  • HLA-A Antigens 65%
• Edited Book

  Immunoinformatics: predicting immunogenicity in silico

  Flower, D. R. (ed.), 16 Jul 2007, Totowa, NJ (US): Humana Press. 438 p. (Methods in molecular biology; vol. 409)

  Research output: Book/Report › Edited Book

  • immunoinformatics 100%
  • immunogenicity 65%
  • vaccine development 34%
  • immunology 34%
  • immune system 26%
• Foreword/postscript

  Preface

  Flower, D. R., 16 Jul 2007, Immunoinformatics: predicting immunogenicity in silico. Flower, D. R. (ed.). Totowa, NJ (US): Humana Press, p. v-vi 2 p. (Methods in molecular miology™; vol. 409).

  Research output: Chapter in Book/Published conference output › Foreword/postscript