In vitro bioactivity of titanium-doped bioglass

Imran M. Asif; Richard M. Shelton; Paul R. Cooper; Owen Addison; Richard A. Martin

doi:10.1007/s10856-014-5230-4

In vitro bioactivity of titanium-doped bioglass

Imran M. Asif, Richard M. Shelton, Paul R. Cooper, Owen Addison, Richard A. Martin^*

^*Corresponding author for this work

Aston University

Research output: Contribution to journal › Article › peer-review

Abstract

Previous studies have suggested that incorporating relatively small quantities of titanium dioxide into bioactive glasses may result in an increase in bioactivity and hydroxyapatite formation. The present work therefore investigated the in vitro bioactivity of a titanium doped bioglass and compared the results with 45S5 bioglass. Apatite formation was evaluated for bioglass and Ti-bioglass in the presence and absence of foetal calf serum. Scanning electron microscopy (SEM) images were used to evaluate the surface development and energy dispersive X-ray measurements provided information on the elemental ratios. X-ray diffraction spectra confirmed the presence of apatite formation. Cell viability was assessed for bone marrow stromal cells under direct and indirect contact conditions and cell adhesion was assessed using SEM.

Original language	English
Pages (from-to)	1865-1873
Number of pages	9
Journal	Journal of Materials Science : Materials in Medicine
Volume	25
Issue number	8
Early online date	7 May 2014
DOIs	https://doi.org/10.1007/s10856-014-5230-4
Publication status	Published - Aug 2014

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The final publication is available at Springer via http://dx.doi.org/10.1007/s10856-014-5230-4

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10.1007/s10856-014-5230-4

In vitro bioactivity of titanium-doped bioglass
The final publication is available at Springer via http://dx.doi.org/10.1007/s10856-014-5230-4
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title = "In vitro bioactivity of titanium-doped bioglass",

abstract = "Previous studies have suggested that incorporating relatively small quantities of titanium dioxide into bioactive glasses may result in an increase in bioactivity and hydroxyapatite formation. The present work therefore investigated the in vitro bioactivity of a titanium doped bioglass and compared the results with 45S5 bioglass. Apatite formation was evaluated for bioglass and Ti-bioglass in the presence and absence of foetal calf serum. Scanning electron microscopy (SEM) images were used to evaluate the surface development and energy dispersive X-ray measurements provided information on the elemental ratios. X-ray diffraction spectra confirmed the presence of apatite formation. Cell viability was assessed for bone marrow stromal cells under direct and indirect contact conditions and cell adhesion was assessed using SEM.",

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AU - Asif, Imran M.

AU - Shelton, Richard M.

AU - Cooper, Paul R.

AU - Addison, Owen

AU - Martin, Richard A.

N1 - The final publication is available at Springer via http://dx.doi.org/10.1007/s10856-014-5230-4

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N2 - Previous studies have suggested that incorporating relatively small quantities of titanium dioxide into bioactive glasses may result in an increase in bioactivity and hydroxyapatite formation. The present work therefore investigated the in vitro bioactivity of a titanium doped bioglass and compared the results with 45S5 bioglass. Apatite formation was evaluated for bioglass and Ti-bioglass in the presence and absence of foetal calf serum. Scanning electron microscopy (SEM) images were used to evaluate the surface development and energy dispersive X-ray measurements provided information on the elemental ratios. X-ray diffraction spectra confirmed the presence of apatite formation. Cell viability was assessed for bone marrow stromal cells under direct and indirect contact conditions and cell adhesion was assessed using SEM.

AB - Previous studies have suggested that incorporating relatively small quantities of titanium dioxide into bioactive glasses may result in an increase in bioactivity and hydroxyapatite formation. The present work therefore investigated the in vitro bioactivity of a titanium doped bioglass and compared the results with 45S5 bioglass. Apatite formation was evaluated for bioglass and Ti-bioglass in the presence and absence of foetal calf serum. Scanning electron microscopy (SEM) images were used to evaluate the surface development and energy dispersive X-ray measurements provided information on the elemental ratios. X-ray diffraction spectra confirmed the presence of apatite formation. Cell viability was assessed for bone marrow stromal cells under direct and indirect contact conditions and cell adhesion was assessed using SEM.

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In vitro bioactivity of titanium-doped bioglass

Abstract

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