In vitro chronic neurotoxicity assays: Present and future developments

Research output: Chapter in Book/Published conference outputChapter

Abstract

Pressure from our aging population’s vulnerability to neurodegenerative disease necessitates the development of experimental platforms to research brain pathology and new drug design, as well as the detection of toxic impact on both the adult and developing CNS. Although exciting human stem cell models are under development, the NT2.D1 teratocarcinoma model differentiates into a co-culture of neurones and astrocytes which, combined with bioreactors and models of the human blood brain barrier such as hCMEC/D3 cells, affords probably the most relevant and flexible opportunity available to investigate teratogenic and toxic chemical impact on the most basic functional and structural aspects of the human CNS.

Original languageEnglish
Title of host publicationComprehensive Biotechnology
PublisherElsevier
Chapter5.39
Pages520-534
Number of pages15
Edition3
ISBN (Electronic)9780444640475
ISBN (Print)9780444640468
DOIs
Publication statusPublished - 1 Jan 2019

Keywords

  • Astrocyte
  • Bioreactor
  • Blood-brain barrier
  • Co-culture
  • Differentiation
  • hCMEC/D3
  • Human
  • Neuron
  • NT2.D1
  • Stem cell
  • Teratogenicity

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