In-vivo corneal confocal microscopy:: Imaging analysis, biological insights and future directions

Jeremy Chung Bo Chiang; Maitreyee Roy; Juno Kim; Maria Markoulli; Arun V. Krishnan

doi:10.1038/s42003-023-05005-8

In-vivo corneal confocal microscopy: Imaging analysis, biological insights and future directions

Jeremy Chung Bo Chiang
, Maitreyee Roy
, Juno Kim
, Maria Markoulli
, Arun V. Krishnan^*

^*Corresponding author for this work

University of New South Wales, School of Optometry and Vision Science, Faculty of Medicine and Health, Sydney, NSW, Australia, GRID: grid.1005.4, ISNI: 0000 0004 4902 0432
Prince of Wales Hospital, Department of Neurology, Sydney, NSW, Australia, GRID: grid.415193.b

Research output: Contribution to journal › Review article › peer-review

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Abstract

In-vivo corneal confocal microscopy is a powerful imaging technique which provides clinicians and researcher with the capabilities to observe microstructures at the ocular surfaces in significant detail. In this Mini Review, the optics and image analysis methods with the use of corneal confocal microscopy are discussed. While novel insights of neuroanatomy and biology of the eyes, particularly the ocular surface, have been provided by corneal confocal microscopy, some debatable elements observed using this technique remain and these are explored in this Mini Review. Potential improvements in imaging methodology and instrumentation are also suggested.

Original language	English
Article number	652
Number of pages	7
Journal	Communications Biology
Volume	6
Issue number	1
Early online date	19 Jun 2023
DOIs	https://doi.org/10.1038/s42003-023-05005-8
Publication status	Published - 19 Jun 2023

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10.1038/s42003-023-05005-8Licence: CC BY 4.0

Chiangetal_2023_VoR
Copyright © The Author(s) 2023. This article is licensed under a Creative Commons Attribution 4.0 International License.
Final published version, 820 KBLicence: CC BY 4.0

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abstract = "In-vivo corneal confocal microscopy is a powerful imaging technique which provides clinicians and researcher with the capabilities to observe microstructures at the ocular surfaces in significant detail. In this Mini Review, the optics and image analysis methods with the use of corneal confocal microscopy are discussed. While novel insights of neuroanatomy and biology of the eyes, particularly the ocular surface, have been provided by corneal confocal microscopy, some debatable elements observed using this technique remain and these are explored in this Mini Review. Potential improvements in imaging methodology and instrumentation are also suggested.",

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AB - In-vivo corneal confocal microscopy is a powerful imaging technique which provides clinicians and researcher with the capabilities to observe microstructures at the ocular surfaces in significant detail. In this Mini Review, the optics and image analysis methods with the use of corneal confocal microscopy are discussed. While novel insights of neuroanatomy and biology of the eyes, particularly the ocular surface, have been provided by corneal confocal microscopy, some debatable elements observed using this technique remain and these are explored in this Mini Review. Potential improvements in imaging methodology and instrumentation are also suggested.

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In-vivo corneal confocal microscopy: Imaging analysis, biological insights and future directions

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