Influence of light exposure during early life on the age of onset of bipolar disorder

Michael Bauer; Tasha Glenn; Martin Alda; Ole A. Andreassen; Elias Angelopoulos; Raffaella Ardau; Christopher Baethge; Rita Bauer; Bernhard T. Baune; Frank Bellivier; Robert H. Belmaker; Michael Berk; Thomas D. Bjella; Letizia Bossini; Yuly Bersudsky; Eric Yat Wo Cheung; Jörn Conell; Maria del Zompo; Seetal Dodd; Bruno Etain; Andrea Fagiolini; Mark A. Frye; Kostas N. Fountoulakis; Jade Garneau-Fournier; Ana Gonzalez-Pinto; John F. Gottlieb; Hirohiko Harima; Stefanie Hassel; Chantal Henry; Apostolos Iacovides; Erkki T. Isometsä; Flávio Kapczinski; Sebastian Kliwicki; Barbara König; Rikke Krogh; Ute Lewitzka; Carlos Lopez-Jaramillo; Glenda M. MacQueen; Mirko Manchia; Wendy Marsh; Mónica Martinez-Cengotitabengoa; Ingrid Melle; Scott Monteith; Gunnar Morken; Rodrigo Munoz; Fabiano G. Nery; Claire O'Donovan; Yamima Osher; Andrea Pfennig; Danilo Quiroz; Raj Ramesar; Natalie Rasgon; Andreas Reif; Philipp Ritter; Janusz K. Rybakowski; Kemal Sagduyu; Ângela M. Scippa; Emanuel Severus; Christian Simhandl; Dan J. Stein; Sergio Strejilevich; Ahmad Hatim Sulaiman; Kirsi Suominen; Hiromi Tagata; Yoshitaka Tatebayashi; Carla Torrent; Eduard Vieta; Biju Viswanath; Mihir J. Wanchoo; Mark Zetin; Peter C. Whybrow

doi:10.1016/j.jpsychires.2015.03.013

Influence of light exposure during early life on the age of onset of bipolar disorder

Michael Bauer
, Tasha Glenn
, Martin Alda
, Ole A. Andreassen
, Elias Angelopoulos
, Raffaella Ardau
, Christopher Baethge
, Rita Bauer
, Bernhard T. Baune
, Frank Bellivier
, Robert H. Belmaker
, Michael Berk
, Thomas D. Bjella
, Letizia Bossini
, Yuly Bersudsky
, Eric Yat Wo Cheung
, Jörn Conell
, Maria del Zompo
, Seetal Dodd
, Bruno Etain

Andrea Fagiolini, Mark A. Frye, Kostas N. Fountoulakis, Jade Garneau-Fournier, Ana Gonzalez-Pinto, John F. Gottlieb, Hirohiko Harima, Stefanie Hassel, Chantal Henry, Apostolos Iacovides, Erkki T. Isometsä, Flávio Kapczinski, Sebastian Kliwicki, Barbara König, Rikke Krogh, Ute Lewitzka, Carlos Lopez-Jaramillo, Glenda M. MacQueen, Mirko Manchia, Wendy Marsh, Mónica Martinez-Cengotitabengoa, Ingrid Melle, Scott Monteith, Gunnar Morken, Rodrigo Munoz, Fabiano G. Nery, Claire O'Donovan, Yamima Osher, Andrea Pfennig, Danilo Quiroz, Raj Ramesar, Natalie Rasgon, Andreas Reif, Philipp Ritter, Janusz K. Rybakowski, Kemal Sagduyu, Ângela M. Scippa, Emanuel Severus, Christian Simhandl, Dan J. Stein, Sergio Strejilevich, Ahmad Hatim Sulaiman, Kirsi Suominen, Hiromi Tagata, Yoshitaka Tatebayashi, Carla Torrent, Eduard Vieta, Biju Viswanath, Mihir J. Wanchoo, Mark Zetin, Peter C. Whybrow

College of Health and Life Sciences

Technische Universität Dresden
ChronoRecord Association
Dalhousie University
Ullevål University Hospital
National and Kapodistrian University of Athens
Ospedale Universitario di Cagliari
University of Adelaide
Universidad del País Vasco
Northwestern University, Evanston
University of Calgary
Johann Wolfgang Goethe-Universität Frankfurt am Main
Universität zu Köln
Université Paris Diderot
FondaMental Fondation
Ben-Gurion University of the Negev
Deakin University
University of Melbourne
Rikshospitalet University Hospital
Universitetet i Oslo
Università degli Studi di Siena
Azienda Ospedaliera Universitaria Senese
Castle Peak Hospital
Università degli Studi di Cagliari
Université Paris-Est
Mayo Clinic
Aristotle University of Thessaloniki
Stanford University
Tokyo Metropolitan Matsuzawa Hospital
Helsingin yliopisto
Finnish National Institute for Health and Welfare
Universidade Federal do Rio Grande do Sul
Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu
BIPOLAR Zentrum Wiener Neustadt
Aarhus University Hospital
Universidad de Antioquia
University of Massachusetts Medical School
Michigan State University
St. Olavs Hospital Universitetssykehuset i Trondheim
Norges Teknisk-Naturvitenskapelige Universitet
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Universidade de São Paulo
Diego Portales University
University of Cape Town
University of Missouri–Kansas City
Universidade Federal da Bahia
Universidad Favaloro
University of Malaya
City of Helsinki
Tokyo Metropolitan Institute of Medical Science
Universitat Autònoma de Barcelona
National Institute of Mental Health and Neurosciences
Chapman University
University of California Los Angeles

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Abstract

Background: Environmental conditions early in life may imprint the circadian system and influence response to environmental signals later in life. We previously determined that a large springtime increase in solar insolation at the onset location was associated with a younger age of onset of bipolar disorder, especially with a family history of mood disorders. This study investigated whether the hours of daylight at the birth location affected this association.
Methods: Data collected previously at 36 collection sites from 23 countries were available for 3896 patients with bipolar I disorder, born between latitudes of 1.4N and 70.7N, and 1.2S and 41.3S. Hours of daylight variables for the birth location were added to a base model to assess the relation between the age of onset and solar insolation.
Results: More hours of daylight at the birth location during early life was associated with an older age of onset, suggesting reduced vulnerability to the future circadian challenge of the springtime increase in solar insolation at the onset location. Addition of the minimum of the average monthly hours of daylight during the first 3 months of life improved the base model, with a significant positive relationship to age of onset. Coefficients for all other variables remained stable, significant and consistent with the base model.
Conclusions: Light exposure during early life may have important consequences for those who are susceptible to bipolar disorder, especially at latitudes with little natural light in winter. This study indirectly supports the concept that early life exposure to light may affect the long term adaptability to respond to a circadian challenge later in life.

Original language	English
Journal	Journal of Psychiatric Research
Volume	In Press
Early online date	27 Mar 2015
DOIs	https://doi.org/10.1016/j.jpsychires.2015.03.013
Publication status	Published - 2015

Bibliographical note

NOTICE: this is the author’s version of a work that was accepted for publication in Journal of psychiatric research. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Bauer, M., Glenn, T., Alda, M., Andreassen, O. A., Angelopoulos, E., Ardau, R., ... Whybrow, P. C. (2015). Influence of light exposure during early life on the age of onset of bipolar disorder. Journal of psychiatric research, In Press (2015) DOI http://dx.doi.org/10.1016/j.jpsychires.2015.03.013

Keywords

bipolar disorder
hours of daylight
insolation
sunlight
age of onset

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10.1016/j.jpsychires.2015.03.013

Influence of light exposure during early life on the age of onset of bipolar disorder
NOTICE: this is the author’s version of a work that was accepted for publication in Journal of psychiatric research. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Bauer, M., Glenn, T., Alda, M., Andreassen, O. A., Angelopoulos, E., Ardau, R., ... Whybrow, P. C. (2015). Influence of light exposure during early life on the age of onset of bipolar disorder. Journal of psychiatric research, In Press (2015) DOI http://dx.doi.org/10.1016/j.jpsychires.2015.03.013
Accepted author manuscript, 255 KB

Cite this

Bauer, M., Glenn, T., Alda, M., Andreassen, O. A., Angelopoulos, E., Ardau, R., Baethge, C., Bauer, R., Baune, B. T., Bellivier, F., Belmaker, R. H., Berk, M., Bjella, T. D., Bossini, L., Bersudsky, Y., Cheung, E. Y. W., Conell, J., del Zompo, M., Dodd, S., ... Whybrow, P. C. (2015). Influence of light exposure during early life on the age of onset of bipolar disorder. Journal of Psychiatric Research, In Press. https://doi.org/10.1016/j.jpsychires.2015.03.013

@article{69550b8064c1466681fc84d1c7ee21ae,

title = "Influence of light exposure during early life on the age of onset of bipolar disorder",

abstract = "Background: Environmental conditions early in life may imprint the circadian system and influence response to environmental signals later in life. We previously determined that a large springtime increase in solar insolation at the onset location was associated with a younger age of onset of bipolar disorder, especially with a family history of mood disorders. This study investigated whether the hours of daylight at the birth location affected this association. Methods: Data collected previously at 36 collection sites from 23 countries were available for 3896 patients with bipolar I disorder, born between latitudes of 1.4N and 70.7N, and 1.2S and 41.3S. Hours of daylight variables for the birth location were added to a base model to assess the relation between the age of onset and solar insolation. Results: More hours of daylight at the birth location during early life was associated with an older age of onset, suggesting reduced vulnerability to the future circadian challenge of the springtime increase in solar insolation at the onset location. Addition of the minimum of the average monthly hours of daylight during the first 3 months of life improved the base model, with a significant positive relationship to age of onset. Coefficients for all other variables remained stable, significant and consistent with the base model. Conclusions: Light exposure during early life may have important consequences for those who are susceptible to bipolar disorder, especially at latitudes with little natural light in winter. This study indirectly supports the concept that early life exposure to light may affect the long term adaptability to respond to a circadian challenge later in life.",

keywords = "bipolar disorder, hours of daylight, insolation, sunlight, age of onset",

author = "Michael Bauer and Tasha Glenn and Martin Alda and Andreassen, \{Ole A.\} and Elias Angelopoulos and Raffaella Ardau and Christopher Baethge and Rita Bauer and Baune, \{Bernhard T.\} and Frank Bellivier and Belmaker, \{Robert H.\} and Michael Berk and Bjella, \{Thomas D.\} and Letizia Bossini and Yuly Bersudsky and Cheung, \{Eric Yat Wo\} and J{\"o}rn Conell and \{del Zompo\}, Maria and Seetal Dodd and Bruno Etain and Andrea Fagiolini and Frye, \{Mark A.\} and Fountoulakis, \{Kostas N.\} and Jade Garneau-Fournier and Ana Gonzalez-Pinto and Gottlieb, \{John F.\} and Hirohiko Harima and Stefanie Hassel and Chantal Henry and Apostolos Iacovides and Isomets{\"a}, \{Erkki T.\} and Fl{\'a}vio Kapczinski and Sebastian Kliwicki and Barbara K{\"o}nig and Rikke Krogh and Ute Lewitzka and Carlos Lopez-Jaramillo and MacQueen, \{Glenda M.\} and Mirko Manchia and Wendy Marsh and M{\'o}nica Martinez-Cengotitabengoa and Ingrid Melle and Scott Monteith and Gunnar Morken and Rodrigo Munoz and Nery, \{Fabiano G.\} and Claire O'Donovan and Yamima Osher and Andrea Pfennig and Danilo Quiroz and Raj Ramesar and Natalie Rasgon and Andreas Reif and Philipp Ritter and Rybakowski, \{Janusz K.\} and Kemal Sagduyu and Scippa, \{{\^A}ngela M.\} and Emanuel Severus and Christian Simhandl and Stein, \{Dan J.\} and Sergio Strejilevich and \{Hatim Sulaiman\}, Ahmad and Kirsi Suominen and Hiromi Tagata and Yoshitaka Tatebayashi and Carla Torrent and Eduard Vieta and Biju Viswanath and Wanchoo, \{Mihir J.\} and Mark Zetin and Whybrow, \{Peter C.\}",

note = "NOTICE: this is the author{\textquoteright}s version of a work that was accepted for publication in Journal of psychiatric research. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Bauer, M., Glenn, T., Alda, M., Andreassen, O. A., Angelopoulos, E., Ardau, R., ... Whybrow, P. C. (2015). Influence of light exposure during early life on the age of onset of bipolar disorder. Journal of psychiatric research, In Press (2015) DOI http://dx.doi.org/10.1016/j.jpsychires.2015.03.013",

year = "2015",

doi = "10.1016/j.jpsychires.2015.03.013",

language = "English",

volume = "In Press",

journal = "Journal of Psychiatric Research",

issn = "0022-3956",

publisher = "Elsevier",

}

Bauer, M, Glenn, T, Alda, M, Andreassen, OA, Angelopoulos, E, Ardau, R, Baethge, C, Bauer, R, Baune, BT, Bellivier, F, Belmaker, RH, Berk, M, Bjella, TD, Bossini, L, Bersudsky, Y, Cheung, EYW, Conell, J, del Zompo, M, Dodd, S, Etain, B, Fagiolini, A, Frye, MA, Fountoulakis, KN, Garneau-Fournier, J, Gonzalez-Pinto, A, Gottlieb, JF, Harima, H, Hassel, S, Henry, C, Iacovides, A, Isometsä, ET, Kapczinski, F, Kliwicki, S, König, B, Krogh, R, Lewitzka, U, Lopez-Jaramillo, C, MacQueen, GM, Manchia, M, Marsh, W, Martinez-Cengotitabengoa, M, Melle, I, Monteith, S, Morken, G, Munoz, R, Nery, FG, O'Donovan, C, Osher, Y, Pfennig, A, Quiroz, D, Ramesar, R, Rasgon, N, Reif, A, Ritter, P, Rybakowski, JK, Sagduyu, K, Scippa, ÂM, Severus, E, Simhandl, C, Stein, DJ, Strejilevich, S, Hatim Sulaiman, A, Suominen, K, Tagata, H, Tatebayashi, Y, Torrent, C, Vieta, E, Viswanath, B, Wanchoo, MJ, Zetin, M & Whybrow, PC 2015, 'Influence of light exposure during early life on the age of onset of bipolar disorder', Journal of Psychiatric Research, vol. In Press. https://doi.org/10.1016/j.jpsychires.2015.03.013

TY - JOUR

T1 - Influence of light exposure during early life on the age of onset of bipolar disorder

AU - Bauer, Michael

AU - Glenn, Tasha

AU - Alda, Martin

AU - Andreassen, Ole A.

AU - Angelopoulos, Elias

AU - Ardau, Raffaella

AU - Baethge, Christopher

AU - Bauer, Rita

AU - Baune, Bernhard T.

AU - Bellivier, Frank

AU - Belmaker, Robert H.

AU - Berk, Michael

AU - Bjella, Thomas D.

AU - Bossini, Letizia

AU - Bersudsky, Yuly

AU - Cheung, Eric Yat Wo

AU - Conell, Jörn

AU - del Zompo, Maria

AU - Dodd, Seetal

AU - Etain, Bruno

AU - Fagiolini, Andrea

AU - Frye, Mark A.

AU - Fountoulakis, Kostas N.

AU - Garneau-Fournier, Jade

AU - Gonzalez-Pinto, Ana

AU - Gottlieb, John F.

AU - Harima, Hirohiko

AU - Hassel, Stefanie

AU - Henry, Chantal

AU - Iacovides, Apostolos

AU - Isometsä, Erkki T.

AU - Kapczinski, Flávio

AU - Kliwicki, Sebastian

AU - König, Barbara

AU - Krogh, Rikke

AU - Lewitzka, Ute

AU - Lopez-Jaramillo, Carlos

AU - MacQueen, Glenda M.

AU - Manchia, Mirko

AU - Marsh, Wendy

AU - Martinez-Cengotitabengoa, Mónica

AU - Melle, Ingrid

AU - Monteith, Scott

AU - Morken, Gunnar

AU - Munoz, Rodrigo

AU - Nery, Fabiano G.

AU - O'Donovan, Claire

AU - Osher, Yamima

AU - Pfennig, Andrea

AU - Quiroz, Danilo

AU - Ramesar, Raj

AU - Rasgon, Natalie

AU - Reif, Andreas

AU - Ritter, Philipp

AU - Rybakowski, Janusz K.

AU - Sagduyu, Kemal

AU - Scippa, Ângela M.

AU - Severus, Emanuel

AU - Simhandl, Christian

AU - Stein, Dan J.

AU - Strejilevich, Sergio

AU - Hatim Sulaiman, Ahmad

AU - Suominen, Kirsi

AU - Tagata, Hiromi

AU - Tatebayashi, Yoshitaka

AU - Torrent, Carla

AU - Vieta, Eduard

AU - Viswanath, Biju

AU - Wanchoo, Mihir J.

AU - Zetin, Mark

AU - Whybrow, Peter C.

N1 - NOTICE: this is the author’s version of a work that was accepted for publication in Journal of psychiatric research. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Bauer, M., Glenn, T., Alda, M., Andreassen, O. A., Angelopoulos, E., Ardau, R., ... Whybrow, P. C. (2015). Influence of light exposure during early life on the age of onset of bipolar disorder. Journal of psychiatric research, In Press (2015) DOI http://dx.doi.org/10.1016/j.jpsychires.2015.03.013

PY - 2015

Y1 - 2015

N2 - Background: Environmental conditions early in life may imprint the circadian system and influence response to environmental signals later in life. We previously determined that a large springtime increase in solar insolation at the onset location was associated with a younger age of onset of bipolar disorder, especially with a family history of mood disorders. This study investigated whether the hours of daylight at the birth location affected this association. Methods: Data collected previously at 36 collection sites from 23 countries were available for 3896 patients with bipolar I disorder, born between latitudes of 1.4N and 70.7N, and 1.2S and 41.3S. Hours of daylight variables for the birth location were added to a base model to assess the relation between the age of onset and solar insolation. Results: More hours of daylight at the birth location during early life was associated with an older age of onset, suggesting reduced vulnerability to the future circadian challenge of the springtime increase in solar insolation at the onset location. Addition of the minimum of the average monthly hours of daylight during the first 3 months of life improved the base model, with a significant positive relationship to age of onset. Coefficients for all other variables remained stable, significant and consistent with the base model. Conclusions: Light exposure during early life may have important consequences for those who are susceptible to bipolar disorder, especially at latitudes with little natural light in winter. This study indirectly supports the concept that early life exposure to light may affect the long term adaptability to respond to a circadian challenge later in life.

AB - Background: Environmental conditions early in life may imprint the circadian system and influence response to environmental signals later in life. We previously determined that a large springtime increase in solar insolation at the onset location was associated with a younger age of onset of bipolar disorder, especially with a family history of mood disorders. This study investigated whether the hours of daylight at the birth location affected this association. Methods: Data collected previously at 36 collection sites from 23 countries were available for 3896 patients with bipolar I disorder, born between latitudes of 1.4N and 70.7N, and 1.2S and 41.3S. Hours of daylight variables for the birth location were added to a base model to assess the relation between the age of onset and solar insolation. Results: More hours of daylight at the birth location during early life was associated with an older age of onset, suggesting reduced vulnerability to the future circadian challenge of the springtime increase in solar insolation at the onset location. Addition of the minimum of the average monthly hours of daylight during the first 3 months of life improved the base model, with a significant positive relationship to age of onset. Coefficients for all other variables remained stable, significant and consistent with the base model. Conclusions: Light exposure during early life may have important consequences for those who are susceptible to bipolar disorder, especially at latitudes with little natural light in winter. This study indirectly supports the concept that early life exposure to light may affect the long term adaptability to respond to a circadian challenge later in life.

KW - bipolar disorder

KW - hours of daylight

KW - insolation

KW - sunlight

KW - age of onset

U2 - 10.1016/j.jpsychires.2015.03.013

DO - 10.1016/j.jpsychires.2015.03.013

M3 - Article

SN - 0022-3956

VL - In Press

JO - Journal of Psychiatric Research

JF - Journal of Psychiatric Research

ER -

Influence of light exposure during early life on the age of onset of bipolar disorder

Abstract

Bibliographical note

Keywords

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