Infrared laser pulse triggers increased singlet oxygen production in tumour cells

S. G. Sokolovski; S. A. Zolotovskaya; A. Goltsov; C. Pourreyron; A. P. South; E. U. Rafailov

doi:10.1038/srep03484

Infrared laser pulse triggers increased singlet oxygen production in tumour cells

S. G. Sokolovski^*
, S. A. Zolotovskaya
, A. Goltsov
, C. Pourreyron
, A. P. South
, E. U. Rafailov

^*Corresponding author for this work

University of Dundee
Abertay University

Research output: Contribution to journal › Article › peer-review

62 Citations (Scopus)

22 Downloads (Pure)

Abstract

Photodynamic therapy (PDT) is a technique developed to treat the ever-increasing global incidence of cancer. This technique utilises singlet oxygen (¹O₂) generation via a laser excited photosensitiser (PS) to kill cancer cells. However, prolonged sensitivity to intensive light (6-8 weeks for lung cancer), relatively low tissue penetration by activating light (630nm up to 4mm), and the cost of PS administration can limit progressive PDT applications. The development of quantum-dot laser diodes emitting in the highest absorption region (1268nm) of triplet oxygen ( ³O₂) presents the possibility of inducing apoptosis in tumour cells through direct ³O₂ → ¹O ₂ transition. Here we demonstrate that a single laser pulse triggers dose-dependent ¹O₂ generation in both normal keratinocytes and tumour cells and show that tumour cells yield the highest ¹O₂ far beyond the initial laser pulse exposure. Our modelling and experimental results support the development of direct infrared (IR) laser-induced tumour treatment as a promising approach in tumour PDT.

Original language	English
Article number	3484
Journal	Scientific Reports
Volume	3
DOIs	https://doi.org/10.1038/srep03484
Publication status	Published - 12 Dec 2013

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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Cite this

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title = "Infrared laser pulse triggers increased singlet oxygen production in tumour cells",

abstract = "Photodynamic therapy (PDT) is a technique developed to treat the ever-increasing global incidence of cancer. This technique utilises singlet oxygen (1O2) generation via a laser excited photosensitiser (PS) to kill cancer cells. However, prolonged sensitivity to intensive light (6-8 weeks for lung cancer), relatively low tissue penetration by activating light (630nm up to 4mm), and the cost of PS administration can limit progressive PDT applications. The development of quantum-dot laser diodes emitting in the highest absorption region (1268nm) of triplet oxygen ( 3O2) presents the possibility of inducing apoptosis in tumour cells through direct 3O2 → 1O 2 transition. Here we demonstrate that a single laser pulse triggers dose-dependent 1O2 generation in both normal keratinocytes and tumour cells and show that tumour cells yield the highest 1O2 far beyond the initial laser pulse exposure. Our modelling and experimental results support the development of direct infrared (IR) laser-induced tumour treatment as a promising approach in tumour PDT.",

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AU - Sokolovski, S. G.

AU - Zolotovskaya, S. A.

AU - Goltsov, A.

AU - Pourreyron, C.

AU - South, A. P.

AU - Rafailov, E. U.

N1 - This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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N2 - Photodynamic therapy (PDT) is a technique developed to treat the ever-increasing global incidence of cancer. This technique utilises singlet oxygen (1O2) generation via a laser excited photosensitiser (PS) to kill cancer cells. However, prolonged sensitivity to intensive light (6-8 weeks for lung cancer), relatively low tissue penetration by activating light (630nm up to 4mm), and the cost of PS administration can limit progressive PDT applications. The development of quantum-dot laser diodes emitting in the highest absorption region (1268nm) of triplet oxygen ( 3O2) presents the possibility of inducing apoptosis in tumour cells through direct 3O2 → 1O 2 transition. Here we demonstrate that a single laser pulse triggers dose-dependent 1O2 generation in both normal keratinocytes and tumour cells and show that tumour cells yield the highest 1O2 far beyond the initial laser pulse exposure. Our modelling and experimental results support the development of direct infrared (IR) laser-induced tumour treatment as a promising approach in tumour PDT.

AB - Photodynamic therapy (PDT) is a technique developed to treat the ever-increasing global incidence of cancer. This technique utilises singlet oxygen (1O2) generation via a laser excited photosensitiser (PS) to kill cancer cells. However, prolonged sensitivity to intensive light (6-8 weeks for lung cancer), relatively low tissue penetration by activating light (630nm up to 4mm), and the cost of PS administration can limit progressive PDT applications. The development of quantum-dot laser diodes emitting in the highest absorption region (1268nm) of triplet oxygen ( 3O2) presents the possibility of inducing apoptosis in tumour cells through direct 3O2 → 1O 2 transition. Here we demonstrate that a single laser pulse triggers dose-dependent 1O2 generation in both normal keratinocytes and tumour cells and show that tumour cells yield the highest 1O2 far beyond the initial laser pulse exposure. Our modelling and experimental results support the development of direct infrared (IR) laser-induced tumour treatment as a promising approach in tumour PDT.

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Infrared laser pulse triggers increased singlet oxygen production in tumour cells

Abstract

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