Inhibition of collagen I accumulation reduces glomerulosclerosis by a Hic-5-dependent mechanism in experimental diabetic nephropathy

Keyphrases

• Collagen I 100%
• Glomerulosclerosis 100%
• Experimental Diabetic Nephropathy 100%
• Hic-5 100%
• Mesangial Cells 36%
• Cell Apoptosis 27%
• Apoptosis 27%
• Mesangium 27%
• α-smooth muscle Actin (α-SMA) 27%
• Positive Feedback Loop 18%
• Myofibroblast Differentiation 18%
• Overexpression 9%
• In Vitro Study 9%
• Cell Attachment 9%
• Cell Behavior 9%
• Transglutaminase 2 Inhibitor 9%
• Knockdown 9%
• Renal Tissue 9%
• Cellular Expression 9%
• Serum Creatinine Level 9%
• Diabetic Glomerulosclerosis 9%
• Glomerular Mesangial Cells 9%
• Proteinurea 9%
• Interstitial Collagens 9%
• Glomerular Deposition 9%
• Cellular Phenotype 9%

Biochemistry, Genetics and Molecular Biology

• Programmed Cell Death 100%
• Mesangial Cell 66%
• Actin 50%
• Transdifferentiation 33%
• Myofibroblast 33%
• Positive Feedback 33%
• In Vitro Study 16%
• Upregulation 16%
• Cell Adhesion 16%
• Transglutaminase 16%
• Creatinine Blood Level 16%

Medicine and Dentistry

• Myofibroblast 33%