Inhibition of dipeptidyl peptidase IV activity as a therapy of Type 2 diabetes

Brian D. Green*, Peter R. Flatt, Clifford J. Bailey

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Dipeptidyl peptidase IV (DPP IV) is a ubiquitous, multifunctional, serine protease enzyme and receptor with roles in the control of endocrine and immune function, cell metabolism, growth and adhesion. As an enzyme, DPP IV cleaves the N-terminal dipeptide from the incretin hormones glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide. This inactivates the hormones, thereby cancelling their prandial insulinotropic effect. One approach to restore incretin activity as a therapy for Type 2 diabetes has been the development of DPP IV inhibitors. Inhibitors of DPP IV have shown efficacy and tolerability when used to control the hyperglycaemia of non-insulin-dependent animal models and human Type 2 diabetes. These DPP IV inhibitors prolong active incretin hormone concentrations and may exert additional antidiabetic effects. If long-term clinical trials confirm sustained and safe control of blood glucose, DPP IV inhibitors (known as 'gliptins') may be expected to provide a new treatment modality for Type 2 diabetes.

Original languageEnglish
Pages (from-to)525-539
Number of pages15
JournalExpert Opinion on Emerging Drugs
Volume11
Issue number3
DOIs
Publication statusPublished - 1 Sep 2006

Keywords

  • Diabetes
  • Dipeptidyl peptidase IV
  • Incretin hormones

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